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Study of Thrombophilia in Recurrent Pregnancy Loss

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Abstract

Objectives

Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss.

Materials and Methods

53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study.

Results

Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level.

Conclusion

This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss.

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Authors and Affiliations

  1. NRS Medical College, Kolkata, India

    Jayasree Hansda (Senior Resident)

  2. Department of OBGY, ESI-Postgraduate Institute and Medical Research, Joka, Kolkata, India

    Joydeb Roychowdhury (Professor & Head)

  3. C/O-Sri R C Hansda, 2/2 Krittibas Road (South), B-Zone, Durgapur, Burdwan, 713205, WB, Kolkata, India

    Jayasree Hansda (Senior Resident)

Authors
  1. Jayasree Hansda
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  2. Joydeb Roychowdhury
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Correspondence to Jayasree Hansda.

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Hansda, J., Roychowdhury, J. Study of Thrombophilia in Recurrent Pregnancy Loss. J Obstet Gynecol India 62, 536–540 (2012). https://doi.org/10.1007/s13224-012-0197-x

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  • DOI: https://doi.org/10.1007/s13224-012-0197-x

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