Good Clinical Practice Recommendations for Iron Deficiency Anemia in Pregnancy (IDA) in Pregnancy in India

Annexure

Anemia Classification

Acquired

• Deficiency anemia (e.g, iron, vitamin B12, folate)

• Hemorrhagic anemia

• Anemia of chronic disease

• Acquired hemolytic anemia

• Aplastic anemia

Inherited

• Thalassemias

• Sickle cell anemia

• Hemoglobinopathies (other than sickle cell anemia)

• Inherited hemolytic anemias

Anemias Classified by Mean Corpuscular Volume

Microcytic (MCV Less than 80 fL)

• Iron deficiency anemia

• Thalassemias

• Anemia of chronic disease

• Sideroblastic anemia

• Anemia associated with copper deficiency

• Anemia associated with lead poisoning

Normocytic (MCV 80–100 fL)

• Hemorrhagic anemia

• Early iron deficiency anemia

• Anemia of chronic disease

• Anemia associated with bone marrow suppression

• Anemia associated with chronic renal insufficiency

• Anemia associated with endocrine dysfunction

• Autoimmune hemolytic anemia

• Anemia associated with hypothyroidism or hypopituitarism

• Hereditary spherocytosis

• Hemolytic anemia associated with paroxysmal nocturnal hemoglobinuria

Macrocytic (MCV Greater than 100 fL)

• Folic acid deficiency anemia

• Anemia associated with vitamin B12 deficiency

• Drug-induced hemolytic anemia (e.g, zidovudine)

• Anemia associated with reticulocytosis

• Anemia associated with liver disease

• Anemia associated with ethanol abuse

• Anemia associated with acute myelodysplastic syndrome

Abbreviation: MCV, mean corpuscular volume

Anemias Characterized by Mechanism

Decreased Red Blood Cell Production

• Iron deficiency anemia

• Anemia associated with vitamin B12 deficiency

• Folic acid deficiency anemia

• Anemia associated with bone marrow disorders

• Anemia associated with bone marrow suppression

• Anemia associated with low levels of erythropoietin

• Anemia associated with hypothyroidism

Increased Red Blood Cell Destruction

• Inherited hemolytic anemias

  • Sickle cell anemia

  • Thalassemia major

  • Hereditary spherocytosis

• Acquired hemolytic anemias

  • Autoimmune hemolytic anemia

  • Hemolytic anemia associated with thrombotic thrombocytopenic purpura

  • Hemolytic anemia associated with hemolytic uremic syndrome

  • Hemolytic anemia associated with malaria

• Hemorrhagic anemia