Skip to main content
SpringerLink
Log in

Role of amnioseal in premature rupture of membranes

  • Original Article
  • Published:
The Journal of Obstetrics and Gynecology of India Aims and scope Submit manuscript

Abstract

Objective

Interleukins (ILs) and matrix metalloproteinases actually target collagen IV in the amniochorion in premature rupture of membranes (PROM), IL-10 acts as a membrane protector. In order to counteract the immunological system involved in the pathogenesis, we have used a combination of proapoptotic bax gene P-53 inhibitor, myristoleate, with antimicrobial peptides, neutrophil defensins, and cytokine IL-10 enhancer.

Methods

A comparative prospective randomized study was conducted from July 2006 to January 2007 in patients (46 cases and 60 controls) attending the Gynecology and Obstetrics Emergency Department, Eden Medical College, Kolkata, complaining of leakage per vagina in their antenatal period between 24 and 36 weeks of gestation. Combination of bax gene inhibitor, antimicrobial peptides, neutrophil defensins, and IL-10 enhancer in scheduled protocol was prescribed and cases followed up as per fixed protocols.

Results

In the 24–30 weeks group, mean prolongation of gestational age was 6.16±3.21 as against 2.66±1.05 (significant), while in 31–36 weeks mean prolongation was 4.69±0.84 as against 4.6±0.632 (significant). In the first group mean birth weight in cases was 1.77±0.66 kg as against 1.2±0.43 kg (significant), while in the second it was 2.18±0.56 kg as against 1.76±0.45 kg (significant). Associated complications were less in cases.

Conclusion

Combination of bax gene inhibitor, antimicrobial peptides, neutrophil defensins, and IL-10 enhancer as per scheduled protocol can be advocated routinely in PROM barring a few situations with excellent fetal and maternal prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mc Parland PC, Taylor DJ. Preterm prelabor rupture of the membranes. In: Bonnar J, Dunlop W (eds) Recent advances in obstetrics and gynaecology, vol 23. Oxford University Press, 2005, p 26.

  2. Mc Parland PC, Bell SC. The fetal membranes and mechanisms underlying their labor associated and prelabor rupture during pregnancy. Fetal Matern Med Rev. 2004; 15: 73–108.

    Article  Google Scholar 

  3. Annells MF, Hart PH, Mullighan CG et al. Interlukins-1,4,6,-10, tumor necrosis factor, transforming growth factor beta, FAS and mannose-binding protein C gene polymorphisms in Australian women: risk of preterm birth. Am J Obstet Gynecol. 2004; 191(6): 2056–2067.

    Article  PubMed  CAS  Google Scholar 

  4. Lannetta O. A new simple test for detecting rupture of the fetal membranes. Obstet Gynecol. 1984; 63(4): 575–576.

    Google Scholar 

  5. Brar M, Bedi PK, Mohinderjit. Comparative evaluation of evaporation test and various other tests for detecting rupture of fetal membranes. J Obstet Gynaecol Ind. 1997; 47: 463–467.

    Google Scholar 

  6. Fortunato SJ, Menon R, Lombardi SJ. Role of tumor necrosis factor-alpha in the premature rupture of membranes and preterm labor pathways. Am J Obstet Gynecol 2002; 187(5): 1159–1162.

    Article  PubMed  CAS  Google Scholar 

  7. Yoon BH, Romero R, Yang SH et al. Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol. 1996; 174(5): 1433–1440.

    Article  PubMed  CAS  Google Scholar 

  8. Yoon BH, Romero R, Park JS et al. Fetal exposure to an intraamniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol. 2000; 182(3): 675–681.

    Article  PubMed  CAS  Google Scholar 

  9. Quesniaux VF. Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview. Res Immunol. 1992; 143(4): 385–400.

    Article  PubMed  CAS  Google Scholar 

  10. Spencer S, Edwin SS, Mitchell MD et al. Interleukin -10 (IL10) inhibits prostaglandin E2 (PGE2) and interleukin — 6 production in human decidual cells: a potential role in preterm labor. J Invest Med 1995; 43: 186–191.

    Google Scholar 

  11. Oliver R, Lamont RF. Role of cytokines in spontaneous preterm labor and preterm birth. In: Studd J (ed) Progress in obstetrics and gynaecology, vol 16. Churchill Livingstone, London, 2004, pp 83–106.

    Google Scholar 

  12. Egarter C, Leitech H, Karas H, et al. Antibiotic treatment in premature rupture of membranes and neonatal morbidity: a metaanalysis. Am J Obstet Gynecol. 1996; 174(2): 589–597.

    Article  PubMed  CAS  Google Scholar 

  13. Newton ER, Prihoda TJ, Gibbs RS. Logistic regression analysis of risk factors for intra-amniotic infection. Obstet Gynecol. 1989; 75(4): 571–575.

    Google Scholar 

  14. Soper DE, Mayhall CG, Dalton HP. Risk factors for intraamniotic infection: a prospective epidemiologic study. Am J Obstet Gynecol. 1989; 161(3): 562–568.

    PubMed  CAS  Google Scholar 

  15. Berkowitz RL, Bonta BW, Warshaw JE. The relationship between premature rupture of membranes and respiratory distress syndrome. Am J Obstet Gynecol. 1976; 124(7): 712–718.

    PubMed  CAS  Google Scholar 

  16. Tejani N, Rebold B, Tuck S, et al. Obstetric factors in the causation of early periventricular-intraventricular hemorrhage. Obstet Gynecol. 1984; 64(4): 510–515.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, India

    Purvita Dam, Somnath Laha, Parnamita Bhattacharya & Pallavi Daga

  2. Dam Purvita 26, Sarat Chatterjee Road, Kolkata, 700089, India

    Purvita Dam

Authors
  1. Purvita Dam
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Somnath Laha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Parnamita Bhattacharya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pallavi Daga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Purvita Dam.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dam, P., Laha, S., Bhattacharya, P. et al. Role of amnioseal in premature rupture of membranes. J Obstet Gynecol India 61, 296–300 (2011). https://doi.org/10.1007/s13224-011-0045-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13224-011-0045-4

Keywords

Search

Navigation