Abstract
Objectives
To evaluate the variations and potential clinical use of second trimester serum markers as predictor of preeclampsia.
Methods
In a prospective study β HCG, α feto protein and inhibin A levels were estimated in 50 antenatal women in the second trimester (12–24 weeks) by ELISA technique. Results were noted in terms of development of preeclampsia, mean serum levels of all three markers, mode of delivery and fetal outcome.
Resuflts
Out of 50 women, 10 developed preeclampsia (20%). A significant rise of mean serum β HCG level (16130.2 MIU/ml, >2.5 MoM,p <0.001), mean serum AFP level (161.7 ng/ml, >2.5 MoM, P<0.001) and mean inhibin-A level (1248.49 pg/ml, >2.0 MoM, P<0.001) was present in those who developed preeclampsia. Out of 10 preeclamptic women one had IUD, four fetuses were growth retarded, two babies were born before term and six were low birth weight babies, whereas out of 40 normotensive women only five had IUGR, three preterm delivery and 32 delivered at term without and complication.
Conclusions
A significant positive correlation between second trimester serum markers and development of preeclampsia was observed (p<0.001). Thus with the second trimester serum marker study, prediction of preeclampsia is possible at incipient stage and its adverse pregnancy outcome can be minimized.
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Dayal, M., Gupta, P., Varma, M. et al. Role of second trimester maternal serum markers as predictor of preeclampsia. J Obstet Gynecol India 61, 38–41 (2011). https://doi.org/10.1007/s13224-011-0014-y
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DOI: https://doi.org/10.1007/s13224-011-0014-y