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A friendly IVF protocol

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Abstract

Objective

To compare the results of a Minimally stimulated Natural cycle IVF with standard long protocol IVF.

Design

A Prospective Study Setting: Private Fertility Institute

Patient(s)

A total of 300 women were recruited of whom 150 cases [Group A] underwent IVF with minimally stimulated natural cycle and 150 controls [Group B] underwent IVF with standard long protocol, with cases and control matched for age, infertility cause, baseline FSH, ovarian reserve and no known male factor as a cause of infertility.

Result(s)

The number of oocytes retrieved was significantly lower for the minimally stimulated natural cycle regimen compared with the standard long protocol[ 4.8 ± 2.6 vs 16.2 ± 7.5 respectively]. The clinical pregnancy rate per transfer, however, was not significantly different between the two regimens [37% Vs 41%, minimally stimulated natural cycle Vs Standard long protocol, respectively].

Conclusion (s)

Minimally stimulated natural cycle IVF is a viable alternative with comparable pregnancy rates to the standard long protocol, and with added advantages of close to zero multiple pregnancy rate, zero risk of ovarian hyper stimulation syndrome, less time consuming, physically and emotionally less demanding for patients and also cost effective.

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References

  1. Delvigne A and Rozenberg S — Review of clinical course and treatment of ovarian hyperstimulation syndrome (OHSS), Hum.Reprod. 2003, 9(1): 77–76

    Article  CAS  Google Scholar 

  2. Koel S., and XItskovitz-Eldor J. — Severe OHSS, Yes, there is a strategy to prevent it. Hum.Reprod. 2000, 15(11): 2266–2267

    Article  Google Scholar 

  3. Macklon N.S. and Fauser B.C.J.M —Regulation of follicle development and Novel approaches to ovarian stimulation for IVF, Hum.Reprod. 2000, 6(4): 307–312

    Article  CAS  Google Scholar 

  4. Aboulghar M.A, Mansour R.T., Serour G.A., et al — In Vitro Fertilisation in a spontaneous cycle: a successful simple protocol. J.Obstet.Gynaecol 1995, 21: 337–340

    CAS  Google Scholar 

  5. Bassil S., Godin P.A. and Donnez. J. — Outcome of In Vitro Fertilisation through natural cycles in poor responders. Hum. Reprod. 1999, 14: 1262–1265

    Article  PubMed  CAS  Google Scholar 

  6. Hohmann F P, Macklon N.S and Fauser Bart.C.J.M — A Randomized comparison of Two ovarian Stimulation protocols with Gonadotropin Releasing Hormone [GnRH] Antagonist cotreatment for Invitro Fertilization commencing Recombinant Follicle Stimulating Hormone on cycle Day 2 or 5 with the standard long GnRH Agonist protocol. J.Clin.Endocrinol.Metab Jan 2003, 88: 166–173

    Article  CAS  Google Scholar 

  7. Giorgetti C, Terriou P, Auquier P, et al — Embryo score to predict implantation after in Vitro Fertilization: based on 957 single Embryo transfers. Hum.Reprod.1995, Sep10(9): 2427–2431

    Google Scholar 

  8. Desai Nina N., Gold Stein J. Rowland Douglas Y. et al — Morphological evaluation of human embryos and derivation of an embryo quality Scoring system specific for day-3 embryos: a preliminary study. Hum.Reprod, 2000, 15(10): 2190–2196

    Article  Google Scholar 

  9. Hesham Al-Inany, Aboulghar M, Gn RH antagonist in assisted Reproduction: a Cochrane review. Hum.Reprod 2002 (17): 874–885

  10. S ladkevicius, Polvilas, Campbell, Stuart — Advanced Ultrasound examination in the management of Subfertility — Current opinion in obs & Gynec June 2000, 12(3): 221–225

    Google Scholar 

  11. Applebaum M. — The uterine biophysical profile. ultrasound obstet Gynecol 1995, Jan 5(1): 67–68

    Article  PubMed  CAS  Google Scholar 

  12. Knight David C, Tyle John PP, Driscol Geoffrey L l- Follicular flushing at oocyte retrieval: a reappraisal. Australian and New Zealand Journal of Obstetrics and Gynaecology 2000, 41[2]: 210–213

    Google Scholar 

  13. Saito Hidekazu, Ishida Gabriela M., Kaneko Tomoka, et al — Application of vitrification to Human Embryo Freezing. Gynecol obstet invest 2000, 49(3): 145–149

    Article  PubMed  CAS  Google Scholar 

  14. Desai N, AbdelHafez F, Falcone T, et al — Pregnancy and live births after transfer of embryos vitrified on day 3 at the 8 cell stage-a three year experience. Fertility and Sterility Sept 2009, 92(3): S188

    Article  Google Scholar 

  15. Trounson A., Anderiesz C. and Jones G., Maturation of human oocytes in vitro and their developmental competence, Reproduction 2001, 121: 51–75

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dr.Rama’s Institute for Fertility, Opp.Chandana Brothers, Ameerpet, Hyderabad, 500016, India

    Papolu Rama Devi, Charulata Chatterjee, A. Rajyalakshmi, P. Navatha & Farah Arshiya

Authors
  1. Papolu Rama Devi
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  2. Charulata Chatterjee
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  3. A. Rajyalakshmi
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  4. P. Navatha
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  5. Farah Arshiya
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Correspondence to Papolu Rama Devi.

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Rama Devi, P., Chatterjee, C., Rajyalakshmi, A. et al. A friendly IVF protocol. J Obstet Gynecol India 61, 77–80 (2011). https://doi.org/10.1007/s13224-011-0006-y

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  • DOI: https://doi.org/10.1007/s13224-011-0006-y

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