Abstract
Objectives
To evaluate the predictive values of urinary calcium creatinine ratio (CCR) and microalbuminuria for preeclampsia.
Methods
Urinary calcium creatinine ratio and microalbuminuria were determined in a spot urine sample in 200 asymptomatic pregnant women between 20–24 weeks of gestation, who attended the antenatal OPD at St John’s Medical College and Hospital. The results were analyzed by Chi square test and Fisher Exact test to find the significant association of findings of preeclampsia and CCR and microalbuminuria. Area under Receiver Operator Curve (ROC) was used to find the predictive values of CCR at less than or equal to 0.04 and microalbuminuria for preeclampsia.
Results
It was found that CCR had a sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of 69.2%, 98.2%, 85.7% and 95.8% respectively with a statistical accuracy of 87% and p value of <0.001 (strongly significant). It was found to be a good test for prediction of preeclampsia. Microalbuminuria had sensitivity, specificity, PPV and NPV of 53.6%, 86%, 36% and 95% and was found to be only a fair test for prediction of preeclampsia.
Conclusion
CCR at 0.04 in spot urine sample being a good test for prediction of preeclampsia can be recommended as a screening test in all asymptomatic pregnant women, for preeclampsia. Microalbuminuria does not seem to be effective as a screening tool for preeclampsia at present.
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Sheela, C.N., Beena, S.R. & Mhaskar, A. Calcium-creatinine ratio and microalbuminuria in prediction of preeclampsia. J Obstet Gynecol India 61, 72–76 (2011). https://doi.org/10.1007/s13224-011-0005-z
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DOI: https://doi.org/10.1007/s13224-011-0005-z