Abstract
Objectives
To compare the outcome with Mifepristone and vaginal Misoprostol combination in women having amenorrhea <-49 days (group-A) verses 50–63 days. (Group-B)
Methods
We administered 200 mg of mifepristone to 200 women willing for medical abortion within 63 days of amenorrhea. After 48 hours they were assigned to receive 400 microgram of misoprostol vaginally. At the end of 4 hours, if required, reinstillation of 400 microgram misoprostol vaginally was done.
Results
Complete abortion rate in women with amenorrhea <-49 days verses 50–63 days were 99.16% and 98.75% respectively. Average duration of bleeding was 6.26 (S, D. 2.43 days ) and 6.98 days (2.26 days)respectively and the difference is statistically significant (p<0.05). The proportion of women with induction abortion interval <-4 hours in the two groups as 83.33% and 72.25% respectively. This difference is statistically not significant (Chi-square=3.47, P>0.05). The success rate at the end of 14 days in group A and B was 99.16% and 98.75% respectively and this difference is statistically not significant. (Chi-square = 0.19, P>0.05)
Conclusions
The combination of oral mifepristone and vaginal misoprostol is currently approved for medical abortion in women with amenorrhoea up to 49 days (7 weeks gestation ). Our study has demonstrated that the use of this combination can be effectively and safely extended for inducing abortions in women with amenorrhoea up to 63 days (9 weeks gestation).
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Deshpande, S., Yelikar, K., Deshmukh, A. et al. “Comparative study of medical abortion by mifepristone with vaginal misoprostol in women < 49 days versus 50–63 days of amenorrhoea”. J Obstet Gynecol India 60, 403–407 (2010). https://doi.org/10.1007/s13224-010-0066-4
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DOI: https://doi.org/10.1007/s13224-010-0066-4