Observation of a mouse sperm motility in a natural uterine tube-inspired microfluidic channel


Bio-inspired engineering has been promisingly spotlighted recently due to the replication of unique natural environments and processes. Fertilization occurs when sperm meets an egg, typically within the uterine tube. Using bio-inspired engineering, we developed natural uterine mimicry for studying sperm motility via the synthetic microfluidic tube system. Mature sperm were collected from the testicular cauda epididymis, and subsequently remained stable for up to 2 days. The primary sperm cells were infused into a single 1.5 cm wrinkle wave patterned microfluidic channel, moving in a prototypical forward sine wave pattern. This study may be useful in understanding the natural behavior of sperm and also may be applied to fertility treatments in the future.

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Correspondence to Soong Ho Um.

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Um, S.H. Observation of a mouse sperm motility in a natural uterine tube-inspired microfluidic channel. BioChip J 7, 46–50 (2013). https://doi.org/10.1007/s13206-013-7107-x

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  • Sperm
  • Microfluidics
  • Bio-inspired engineering