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Development of three-dimensional haptotaxis model for single crawling cell

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Abstract

This paper proposes a three-dimensional diffuse interface dynamic model with multiple mechanisms and confirms the high possibility of adequate predictions. In particular, we consider the nucleus that exhibits three-dimensional motion in the crawling cell, which enables a more realistic representation of haptotactic migration. A diffuse interface model that incorporates the haptotaxis mechanism and interface energies is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation model. The simulation results confirm the reliability of the developed model.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Sogang University, 1 Sinsu-dong, Mapo-gu, Seoul, Korea

    Jihwan Song & Dongchoul Kim

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  1. Jihwan Song
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  2. Dongchoul Kim
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Correspondence to Dongchoul Kim.

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Song, J., Kim, D. Development of three-dimensional haptotaxis model for single crawling cell. BioChip J 4, 184–188 (2010). https://doi.org/10.1007/s13206-010-4304-8

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  • DOI: https://doi.org/10.1007/s13206-010-4304-8

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