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Treadmill exercise with nanoselenium supplementation affects the expression of Irisin/FNDC5 and semaphorin 3A in rats exposed to cigarette smoke extract

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Abstract

In the current study, we investigated the impacts of 6 weeks of aerobic interval training (AIT) with selenium nanoparticles (SeNPs) on muscle, serum, and lung irisin (FNDC5) and Sema3A in rats exposed to cigarette smoke extract (CSE). To this end, 49 male Wistar rats (8 weeks old) were divided into seven groups: control, SeNPs (2.5 mg/kg b.w by oral gavage, 3 days/week, 6 weeks), AIT (49 min/day, 5 days/week for 6 weeks, interval), SeNPs + AIT, CSE (150 µL by IP injection, 1 day/week for 6 weeks), CSE + AIT, and CSE + SeNPs + AIT. The CSE group showed a significant reduction in irisin and Sema3A serum levels, as well as a decrease in FNDC5 and Sema3A gene expression in lung tissue (p < 0.05). A combined treatment (AIT with SeNPs) significantly increased the serum level and the expression of muscle and lung irisin (FNDC5) and Sema3A in CSE received groups (p < 0.05). There was a positive and significant correlation between muscle FNDC5 and lung FNDC5 in the CSE + SeNPs + AIT group (r = 0.92, p = 0.025). In addition, there was a positive and significant correlation between serum Sema3A and lung Sema3A of CSE + SeNPs + AIT group (r = 0.97, p = 0.004). Seemingly, performing aerobic exercises with the antioxidant and anti-inflammatory supplement nano-selenium in the model of lung damage (similar to COPD) can boost myokine irisin and Sema3A, especially in serum and lung tissue. These results displayed the paracrine/endocrine regulatory function of these myokines on other tissues. In other words, these interventions emphasized the creation of crosstalk between skeletal muscles and damaged lung, focusing on its recovery; however, further research is needed.

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Data availability

The data supporting the findings of this study are available on request from the corresponding author.

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Acknowledgements

We would like to express our gratitude to the Tobacco Control Research Center (TCRC) of the Iranian Anti-Tobacco Association for supporting this research project.

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Authors and Affiliations

  1. Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Ehsan Arabzadeh & Hossein Shirvani

  2. Tobacco Control Research Center (TCRC), Iranian Anti-Tobacco Association, Tehran, Iran

    Mohammad Reza Masjedi

  3. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Mostafa Ghanei

  4. Department of Food and Nutrition, Consumer Centre of the German Federal State of Bavaria, Munich, Germany

    Martin Hofmeister

  5. Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran

    Fatemeh Rostamkhani

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  1. Ehsan Arabzadeh
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  4. Mostafa Ghanei
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All authors have participated in drafting the manuscript. All authors reviewed the results and approved the final version of the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.

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Experiments were performed according to NIH Guidelines for the animal study on Wistar rats weighing about 180–220 g bred at the animal laboratory, at Baqiyatallah University of medical sciences, Tehran, Iran (ethical code: IR.BMSU.REC.1400.117).

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Arabzadeh, E., Shirvani, H., Masjedi, M.R. et al. Treadmill exercise with nanoselenium supplementation affects the expression of Irisin/FNDC5 and semaphorin 3A in rats exposed to cigarette smoke extract. 3 Biotech 14, 4 (2024). https://doi.org/10.1007/s13205-023-03849-9

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