Abstract
Mycelia and mushrooms are able to bioaccumulate minerals. Lithium is the active principle of drugs used in the treatment of psychiatric diseases. However, a dietary source of Li can reduce the side effects of these drugs. Thus, the objective of this study was to evaluate the bioavailability of Li-enriched mushroom of Pleurotus djamor in pigs and the effects of this element on oxidative stress in the animal tissues. Pigs 28–30 days-old were fed with diets containing or not Li for five days. Levels of serum cortisol were related to the Li dosage from diet. Li-enriched mushrooms were more bioavailable source of Li to the body than Li2CO3. These mushrooms also improved the effects of oxidative enzymes and showed less oxidative damage than Li2CO3. These results demonstrate the potential to use Li-enriched P. djamor as a source of Li that is more bioavailable and present protective effects against oxidative stress.
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Acknowledgement
The authors are grateful to the Cordenação de Aperfeiçoamento de Pessoal de Nível superior (Capes-0001), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG) for their financial support.
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Conceptualization, Validation, Investigation, Writing, Formal analysis: L. S. Lopes, M.C.S. da Silva, J.S. da Silva, J.M.R. da Luz, A. O. Faustino, Gabriel C. Rocha, L. L. Oliveira, M. C. M, Kasuya. Data processing and analysis: L. S. Lopes, M.C.S. da Silva, J.S. da Silva, J.M.R. da Luz, M. C. M, Kasuya. The investigation, Writing - review & editing: L. S. Lopes, M.C.S. da Silva, J.S. da Silva, J.M.R. da Luz, A. O. Faustino, Gabriel C. Rocha, L. L. Oliveira, M. C. M, Kasuya.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of National Council for the Control of Animal Experimentation (CONCEA, Law number 11,794, of October 8, 2008) and Commission of Ethics in the Use of Animal Production of the Universidade Federal de Viçosa (Protocol No. 02/2021). All participants of the QDA and Napping panels were provided with consent forms before taking part in this study.
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Lopes, L.S., da Silva, M.C.S., da Silva, J.S. et al. Bioavailability of Li-enriched mushrooms and protection against oxidative stress in pigs: First study in vivo. 3 Biotech 13, 334 (2023). https://doi.org/10.1007/s13205-023-03731-8
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DOI: https://doi.org/10.1007/s13205-023-03731-8