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Potential therapeutic targets for combating Mycoplasma genitalium

3 Biotech volume 13, Article number: 9 (2023) Cite this article

Abstract

Mycoplasma genitalium (M. genitalium) has emerged as a sexually transmitted infection (STI) all over the world in the last three decades. It has been identified as a cause of male urethritis, and there is now evidence that it also causes cervicitis and pelvic inflammatory disease in women. However, the precise role of M. genitalium in diseases such as pelvic inflammatory disease, and infertility is unknown, and more research is required. It is a slow-growing organism, and with the advent of the nucleic acid amplification test (NAAT), more studies are being conducted and knowledge about the pathogenicity of this organism is being elucidated. The accumulation of data has improved our understanding of the pathogen and its role in disease transmission. Despite the widespread use of single-dose azithromycin in the sexual health field, M. genitalium is known to rapidly develop antibiotic resistance. As a result, the media frequently refer to this pathogen as the “new STI superbug.” Despite their rarity, antibiotics available today have serious side effects. As the cure rates for first-line antimicrobials have decreased, it is now a challenge to determine the effective antimicrobial therapy. In this review, we summarise recent M. genitalium research and investigate potential therapeutic targets for combating this pathogen.

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Data availability statement

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

Authors thank Central University of South Bihar (CUSB), India for infrastructural support.

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The work presented here is not covered by any funding agency.

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Authors and Affiliations

  1. Department of Bioinformatics, Central University of South Bihar, Gaya, 824236, India

    Krishnendu Barik, Praffulla Kumar Arya, Ajay Kumar Singh & Anil Kumar

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  1. Krishnendu Barik
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  2. Praffulla Kumar Arya
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  3. Ajay Kumar Singh
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  4. Anil Kumar
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Contributions

KB: data collection, compilation, drafting and art work of the manuscript. PKA: editing the manuscript. AKS: manuscript moderation. AK: primary investigator of the work presented.

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Correspondence to Anil Kumar.

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Barik, K., Arya, P.K., Singh, A.K. et al. Potential therapeutic targets for combating Mycoplasma genitalium. 3 Biotech 13, 9 (2023). https://doi.org/10.1007/s13205-022-03423-9

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Keywords

  • Mycoplasma genitalium
  • Urethritis
  • Cervicitis
  • Pelvic inflammatory disease
  • Sexually transmitted infections