Skip to main content

Complete genome sequence of Streptomyces cyanogenus S136, producer of anticancer angucycline landomycin A

Abstract

Streptomyces cyanogenus S136 is the only known producer of landomycin A (LaA), one of the founding members of angucycline family of aromatic polyketides. LaA displays potent anticancer activities which has made this natural product a target of numerous chemical and cell biological studies. Little is known about the potential of S136 strain to produce other secondary metabolites. Here we report complete genome sequence of LaA producer and how we used this sequence to evaluate for this species its phylogenetic position and diversity of gene clusters for natural product biosynthesis.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

Download references

Funding

The work was supported by grants BG-80F and BG-09F from the Ministry of Education and Science of Ukraine (to B.O. and V.F.).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bohdan Ostash.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interests.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (PPTX 3205 KB)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hrab, P., Rückert , C., Busche, T. et al. Complete genome sequence of Streptomyces cyanogenus S136, producer of anticancer angucycline landomycin A. 3 Biotech 11, 282 (2021). https://doi.org/10.1007/s13205-021-02834-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s13205-021-02834-4

Keywords

  • Landomycin A
  • Streptomyces cyanogenus
  • Genomics