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The role of enzymatic activities of antiviral proteins from plants for action against plant pathogens

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Abstract

Antiviral proteins (AVPs) from plants possess multiple activities, such as N-glycosidase, RNase, DNase enzymatic activity, and induce pathogenesis-related proteins, salicylic acid, superoxide dismutase, peroxidase, and catalase. The N-glycosidase activity releases the adenine residues from sarcin/ricin (S/R) loop of large subunit of ribosomes and interfere the host protein synthesis process and this activity has been attributed for antiviral activity in plant. It has been shown that AVP binds directly to viral genome-linked protein of plant viruses and interfere with protein synthesis of virus. AVPs also possess the RNase and DNase like activity and may be targeting nucleic acid of viruses directly. Recently, the antifungal, antibacterial, and antiinsect properties of AVPs have also been demonstrated. Gene encoding for AVPs has been used for the development of transgenic resistant crops to a broad range of plant pathogens and insect pests. However, the cytotoxicity has been observed in transgenic crops using AVP gene in some cases which can be a limiting factor for its application in agriculture. In this review, we have reviewed various aspects of AVPs particularly their characteristics, possible mode of action and application.

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Authors and Affiliations

  1. Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, 201313, India

    Nandlal Choudhary

  2. Division of Biochemistry, Indian Agricultural Research Institute, Pusa, New Delhi, 110012, India

    M. L. Lodha

  3. Division of Plant Pathology, Indian Agricultural Research Institute, Pusa, New Delhi, 110012, India

    V. K. Baranwal

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  1. Nandlal Choudhary
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  3. V. K. Baranwal
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Choudhary, N., Lodha, M.L. & Baranwal, V.K. The role of enzymatic activities of antiviral proteins from plants for action against plant pathogens. 3 Biotech 10, 505 (2020). https://doi.org/10.1007/s13205-020-02495-9

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