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Role of nitric oxide-scavenging activity of Karanjin and Pongapin in the treatment of Psoriasis

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Abstract

In the present study, Karanjin and Pongapin, two important furanoflavone, constituents of Pongamia pinnata were studied in the management of Psoriasis. Presently, we have experimentally studied the free radical quenching property of Karanjin and Pongapin. A modified method was used to estimate the scavenging effect of the Karanjin (the highest activity of 95.60%) and Pongapin (68.05%) compared to the ascorbic acid as standard (11.60%) against nitric oxide. Furthermore, Molecular docking studies were performed using CLC drug discovery workbench software version 3.0 of the studied flavones (Karanjin and Pongapin) with the receptors responsible for psoriasis (viz. IL-17A, IL-17F, IL-23, RORγt, and TLR-7). Docking scores of Karanjin and Pongapin with different studied receptors were found to be comparable to that of Methotrexate, a known drug for treating Psoriasis. Docking results suggest that Karanjin and Pongapin might also help in controlling the disease. Overall, our results indicate that flavones (Karanjin and Pongapin) could be a natural and better alternative in curing psoriasis without any side effects.

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Acknowledgements

We sincerely thank the Department of Science and Technology—WOS (A) and Lincoln University College, Malaysia, for financial assistance. We also thank Prof. Julie Banerji, University of Calcutta, and Dr. Manoj Kar, Nil Ratan Sircar Medical College, Kolkata, India, for the initial help and suggestions.

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Authors and Affiliations

  1. Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata, 700 026, India

    Anindita Ghosh

  2. Lincoln University College, Wisma Lincoln, No. 12-18, Jalan SS 6/12, 47301, Petaling Jaya, Selangor Darul Ehsan, Malaysia

    Gopal J. Tiwari

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  1. Anindita Ghosh
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  2. Gopal J. Tiwari
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Correspondence to Gopal J. Tiwari.

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Ghosh, A., Tiwari, G.J. Role of nitric oxide-scavenging activity of Karanjin and Pongapin in the treatment of Psoriasis. 3 Biotech 8, 338 (2018). https://doi.org/10.1007/s13205-018-1337-5

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