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Renoprotective effect of cinnamaldehyde in food color induced toxicity

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Abstract

Present study reports the effects of metanil yellow, a non-permitted food colouring dye, on the biomarkers of oxidative stress and kidney function in blood and renal tissue of albino Wistar rats and its mitigation by cinnamaldehyde, a major phytoconstituents of cinnamon. Oral administration of metanil yellow in rats caused about 70% reduction in ferric reducing ability (FRAP 5.1 μM/L) and 50% decline in reduced glutathione (GSH 59.27 nM/mg protein) content in plasma with simultaneous increase in serum creatinine level. In kidney tissues, activities of superoxide dismutase (SOD), catalase and GSH dropped while malondialdehyde (MDA) content increased. Co-administration of cinnamaldehyde with metanil yellow showed considerable restorative effect on the biomarkers of plasma antioxidant status and kidney function i.e., FRAP (11.5 μM/L), GSH (83–88.5 nM/mg protein), urea, creatinine, SOD, catalase and MDA. Administration of cinnamaldehyde restored the kidney enzyme activities up to 75% of the base level. The study revealed that reno-protective action of cinnamaldehyde was mediated by lowering oxidative stress level.

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Acknowledgements

UKS, RK, AG and RG acknowledge financial support in the form of UGC CRET fellowships. All authors also acknowledge UGC-SAP and DST-FIST Facilities of the Department of Biochemistry, University of Allahabad, Allahabad.

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  1. Uma Kant Sharma and Ramesh Kumar have contributed equally to this work.

Authors and Affiliations

  1. Department of Biochemistry, University of Allahabad, Allahabad, 211002, India

    Uma Kant Sharma, Ramesh Kumar, Ashutosh Gupta, Risha Ganguly & Abhay K. Pandey

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  1. Uma Kant Sharma
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  2. Ramesh Kumar
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  3. Ashutosh Gupta
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  4. Risha Ganguly
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  5. Abhay K. Pandey
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Correspondence to Abhay K. Pandey.

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Sharma, U.K., Kumar, R., Gupta, A. et al. Renoprotective effect of cinnamaldehyde in food color induced toxicity. 3 Biotech 8, 212 (2018). https://doi.org/10.1007/s13205-018-1241-z

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