Abstract
This research aimed to investigate the efficacy of trans-catheter left gastric artery embolization (LGAE) in the treatment of obesity with type 2 diabetes mellitus (T2DM), and to compare the advantages of thermo-sensitive nano-gel as a vascular embolization agent. In this study, nine healthy adult male beagle dogs were randomly divided into three groups (three dogs in each group) to establish the model of obesity with type 2 diabetes mellitus: a was the general embolization group of type 2 diabetes mellitus, and the embolization group of polyvinyl alcohol drug granules (PVA) by transcatheter left gastric artery embolization; In group B, the embolic agent was replaced by (N- isopropylacrylamide -co- butyl methacrylate) (PIB) temperature-sensitive nano-gel. Group C and the control group were perfused with 12 mL normal saline in the left gastric artery via catheter. The results showed that when the reaction temperature of PIB nanogel was between 60 ℃ and 80 ℃, the particle size fluctuated between (200.59 ± 2.78) and (213.31 ± 1.09) nm, and the phase transition temperature was between 30.1 ℃ and 31.0 ℃. Serum insulin concentration in PIB nanogel group was (19.55 ± 0.2274)uLU/mL lower than that in PVA group (20.89 ± 0.1144)uLU/mL (P < 0.05) and higher than that in the control group (17.72 ± 0.1298)uLU/mL (P < 0.05). The insulin resistance index of the PIB nanogel group (7.260 ± 0.13) was lower than that of PVA group (12.57 ± 0.25) (P < 0.05) and higher than that of the control group (5.015 ± 0.17) (P < 0.05). In conclusion, the thermo-sensitive nano-gel was used as a new vessel embolization agent, and the application of left gastric artery embolization for Beagle dogs with T2DM was beneficial to lower blood sugar, improve insulin resistance, and regulate insulin levels.
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The Joint Fund of National Natural Science Foundation of China (No. U1603127).
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Cao, G., Gu, J., Zhang, H. et al. Treatment of obesity with type 2 diabetes mellitus by trans-catheter left gastric artery embolization under the thermo-sensitive nano-gel vascular embolization agent. Appl Nanosci 13, 3533–3541 (2023). https://doi.org/10.1007/s13204-022-02697-y
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DOI: https://doi.org/10.1007/s13204-022-02697-y