Abstract
This study was to explore the effect of functionalized gold nanomaterials (FGNM) on the detection of bacterial translocation (BT) in patients with acute intestinal obstruction (AIO). In this study, 90 AIO patients were selected and divided into a blank group (group B), a control group (group C), and an experimental group (group E) for surgical treatment. The BT was detected by traditional methods, tissue bacterial culture (TBC) method, and FGNM method. The results showed that the positive detection rate (PTR) of BT in lymph node in the group C and group E was obviously higher than that in group B (P < 0.05); compared with the group B and C, the serum interleukin-10 (IL-10) concentration of group E was much higher (P < 0.05), while there was no visible difference between the IL-10 concentration in group B and C (P > 0.05); the expression of serum transforming growth factor β (TGF-β1) in group C and E was higher obviously in contrast to that of group B (P < 0.05). In short, the FGNM could achieve high sensitivity and accuracy in detecting the PTR of BT in AIO patients. The accuracy of tissue and blood detection was higher in contrast to that of the traditional detection methods. Therefore, it was worth applying the FGNM in the detection of BT in AIO patients.
Similar content being viewed by others
Data availability
All data, models, and code generated or used during the study appear in the submitted article.
References
Alkilany AM, Lohse SE, Murphy CJ (2013) The gold standard: gold nanoparticle libraries to understand the nano-bio interface. Acc Chem Res 46(3):650–661
Bento JH, Bianchi ET, Tustumi F et al (2019) Surgical management of malignant intestinal obstruction: outcome and prognostic factors. Chirurgia (bucur) 114(3):343–351
Burke M, Blikslager A (2018) Advances in diagnostics and treatments in horses with acute colic and postoperative ileus. Vet Clin North Am Equine Pract 34(1):81–96
Catena F, De Simone B, Coccolini F et al (2019) Bowel obstruction: a narrative review for all physicians. World J Emerg Surg 14:20
Colombo C, Ellemunter H, Houwen R et al (2011) Guidelines for the diagnosis and management of distal intestinal obstruction syndrome in cystic fibrosis patients. J Cyst Fibros 10(Suppl 2):S24–S28
Hudson ML, Costello DM, Daley JM et al (2019) Species-specific (hyalella azteca and lymnea stagnalis) dietary accumulation of gold nano-particles associated with periphyton. Bull Environ Contam Toxicol 103(2):255–260
Jackson PG, Raiji MT (2011) Evaluation and management of intestinal obstruction. Am Fam Physician 83(2):159–165
Jackson P, Vigiola CM (2018) Intestinal obstruction: evaluation and management. Am Fam Physician 98(6):362–367
Kreyling WG, Möller W, Holzwarth U et al (2018) Age-dependent rat lung deposition patterns of inhaled 20 nanometer gold nanoparticles and their quantitative biokinetics in adult rats. ACS Nano 12(8):7771–7790
Li W, Jiang X, Xue J et al (2015) Antibody modified gold nano-mushroom arrays for rapid detection of alpha-fetoprotein. Biosens Bioelectron 68:468–474
Lin Y, Ren J, Qu X (2014) Nano-gold as artificial enzymes: hidden talents. Adv Mater 26(25):4200–4217
Pan D, Gu Y, Lan H et al (2015) Functional graphene-gold nano-composite fabricated electrochemical biosensor for direct and rapid detection of bisphenol A. Anal Chim Acta 853:297–302
Polak P, Shefi O (2015) Nanometric agents in the service of neuroscience: manipulation of neuronal growth and activity using nanoparticles. Nanomedicine 11(6):1467–1479
Smith SE, White RA, Grant DA et al (2016) Gold and hydroxyapatite nano-composite scaffolds for anterior cruciate ligament reconstruction: in vitro characterization. J Nanosci Nanotechnol 16(1):1160–1169
Vargas MG, Miguel-Sardaneta ML, Rosas-Téllez M et al (2018) Neonatal intestinal obstruction syndrome. Pediatr Ann 47(5):e220–e225
Wnęk M, Górzny ML, Ward MB et al (2013) Fabrication and characterization of gold nano-wires templated on virus-like arrays of tobacco mosaic virus coat proteins. Nanotechnology 24(2):025605
Yasu T, Ohno N, Kawamata T et al (2016) Vincristine-induced paralytic ileus during induction therapy of treatment protocols for acute lymphoblastic leukemia in adult patients. Int J Clin Pharmacol Ther 54(6):471–473
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
No potential conflict of interest was reported by the author(s).
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Wang, X., Kong, W., Sun, X. et al. Functionalized gold nanomaterials in the detection of bacterial translocation in patients with acute intestinal obstruction. Appl Nanosci 13, 3477–3482 (2023). https://doi.org/10.1007/s13204-022-02557-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13204-022-02557-9