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PTEG, a novel polycation with strong proton-buffering capability in wide pH range: synthesis, proton-buffering capability source and colloidal complexes of DNA

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Abstract

A novel randomly branched polycation with good proton-buffering capability over a wide pH range (named PTEG) and its polyplexes with DNA were prepared and characterized by various techniques. Characterization via 1H NMR, 13C NMR, FTIR, TGA, DSC, element analysis and protonation titration showed the structure and physical, chemical properties of PTEG. Characterization via electrophoresis, dynamic light scattering, zeta potential analysis and AFM showed that PTEG and DNA formed colloidal complexes. The reason of strong proton-buffering capability below pH 7.4 (that is, proton sponge effect) of PTEG was deeply studied and the results showed that it had no relation with amino group kind. The real reason was series-wound coupled amino groups connected by two carbons, which provides a basis for the synthesis of cationic polymers with strong proton sponge effect.

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Acknowledgements

This work was supported by Scientific and Technological Project of Jiangxi Province Education Department (GJJ161063). Professor Xiao-hong Li is thanked very much for the authorized use of many measuring equipments. Chuan-bao Wu sincerely acknowledges Dr. Ye Yang for a lot of measurement help.

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Author notes

  1. Chuan-Bao Wu and Jian-Yuan Hao contributed equally to this work.

Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Jiujiang University, Qianjin Eath Road No. 551, Jiujiang City, 332005, Jiangxi Province, People’s Republic of China

    Chuan-Bao Wu, Kang-Qiang Liu & Xiang-Hui Zeng

  2. Jiangxi Province Engineering Research Center of Ecological Chemical Industry, Jiujiang University, Jiujiang City, Jiangxi Province, People’s Republic of China

    Chuan-Bao Wu, Kang-Qiang Liu & Xiang-Hui Zeng

  3. Institute of Chengdu Organic Chemistry of Chinese Academy of Sciences, Chengdu City, Sichuan Province, People’s Republic of China

    Chuan-Bao Wu

  4. School of Microelectronics and Solid-State Electronics, University of Electronic Science and Technology of China, Chengdu City, Sichuan Province, People’s Republic of China

    Jian-Yuan Hao

  5. College of Physical Education, Jiujiang University, Jiujiang City, Jiangxi Province, People’s Republic of China

    Jian-Yuan Hao & Li-Jiang Liu

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  1. Chuan-Bao Wu
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  2. Jian-Yuan Hao
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  3. Kang-Qiang Liu
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Correspondence to Chuan-Bao Wu.

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Wu, CB., Hao, JY., Liu, KQ. et al. PTEG, a novel polycation with strong proton-buffering capability in wide pH range: synthesis, proton-buffering capability source and colloidal complexes of DNA. Appl Nanosci 12, 2331–2343 (2022). https://doi.org/10.1007/s13204-022-02508-4

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  • DOI: https://doi.org/10.1007/s13204-022-02508-4

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