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Biomedical application of single anatase phase TiO2 nanoparticles with addition of Rambutan (Nephelium lappaceum L.) fruit peel extract

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Abstract

Metal oxide nanoparticles are considered to be an important material due to their good mechanical stability, unique structure and catalytic properties. The hydrothermal method was followed along with rambutan (Nephelium lappaceum L.) fruit peel extract mixed with metal ions to prepare titanium dioxide (TiO2) nanorods. Though there are numerous similar works published in past decades, in comparison with those works, the novelty of this work is using rambutan fruit peel as a precipitation agent. The advantages of using such natural agents are that they are eco-friendly and economically feasible. The prepared TiO2 nanorods were co-cultured with human breast cancer cells (MDA-MB-231) and their cytotoxicity was evaluated. The morphology of the nanorods was analyzed through transmission electron microscopy. The average diameter of the TiO2 nanorods was found to be 70–90 nm. The anatase phase of the tetragonal structure was confirmed through X-ray diffraction analysis. The studies of the vibrational Raman active modes and optical properties confirmed the presence of TiO2. X-ray photoelectron spectroscopy binding energy of Ti2p3/2 determined as 460 eV and that of O1s determined as 532 eV confirmed the presence of TiO2. Cytotoxicity was analyzed using MDA-MB-231 and cell death was observed at 73.65 µg/ml.

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Acknowledgement

This work was supported by MHRD RUSA - Phase 2, UGC-SAP, DST FIST, PURSE grants. The authors extend their appreciation to The Researchers Supporting Project number (RSP-2020/230) King Saudi University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Department of Physics, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India

    M. Isacfranklin, R. Yuvakkumar & G. Ravi

  2. Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India

    P. Kumar

  3. SARP, LARPM, Central Institute of Plastics Engineering and Technology (CIPET), Bhubaneswar, Odisha, 751 024, India

    B. Saravanakumar

  4. Faculty of Engineering and Science, Western Norway University of Applied Sciences, 5063, Bergen, Norway

    Dhayalan Velauthapillai

  5. Department of Pediatrics, College of Medicine, King Saud University, [Medical City], King Khalid University Hospital, PO Box 2925, Riyadh, 11461, Saudi Arabia

    Tahani Awad Alahmadi

  6. Department of Botany and Microbiology, College of Science, King Saudi University, P.O Box 2455, Riyadh, 11451, Saudi Arabia

    Sulaiman Ali Alharbi

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  1. M. Isacfranklin
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  2. R. Yuvakkumar
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  4. P. Kumar
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  5. B. Saravanakumar
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  6. Dhayalan Velauthapillai
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  7. Tahani Awad Alahmadi
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  8. Sulaiman Ali Alharbi
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Correspondence to R. Yuvakkumar or G. Ravi.

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Isacfranklin, M., Yuvakkumar, R., Ravi, G. et al. Biomedical application of single anatase phase TiO2 nanoparticles with addition of Rambutan (Nephelium lappaceum L.) fruit peel extract. Appl Nanosci 11, 699–708 (2021). https://doi.org/10.1007/s13204-020-01599-1

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