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Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery

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Abstract

Microneedle delivery patches are an emerging technology to attain painless and sustained delivery through the epidermis of the skin. This study is unique in its attempt to develop polymeric microneedles embedded with drug. Special polymer chitosan with hydrogel forming capability is cross-linked with PVA, a water-soluble polymer with excellent film strengthening ability and loaded with model drug diclofenac sodium. The microneedle patch was fabricated by pouring the chitosan-PVA solution (ratio 1:6) on negative replica of master mold, which upon drying was peeled off to result in the composite film. The film of chitosan-PVA in the ratio 1:6 when tested for mechanical behavior exhibited improved mechanical strength owing to use of PVA, the presence of effective cross-linking of PVA with chitosan was further verified with FTIR. The release from drug-loaded needles was promising, as cross-linking with PVA enabled a sustained drug release of 20.17% at the end of 30 h. The release followed the Higuchi model with Fickian diffusion, indicating a swelling-dependent release. The microneedle prepared using a composite of chitosan-PVA showed promising results indicating its potential to be used as a drug eluting transdermal patch.

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Acknowledgements

The authors sincerely acknowledge Mr. Shivanand.M.Shettigar, Manipal College of Pharmaceutical Sciences, Manipal and Dr. N.V Anil Kumar, Manipal Institute of Technology, Manipal for their technical support. One of the author would like to acknowledge the funding from Vision Group of Science and Technology (VGST), No. VGST/SMYSR (2014-15)/GRD-448/2015-16 from Govt. of Karnataka, India. Authors sincerely acknowledge Dr. V.H.S.Moorthy and Mr. Venkatesh A of Research laboratory for Plasmonics and Fiona Concy Rodrigues, Department of Biomedical Engineering for their technical support. The authors are grateful for the funding from Manipal University (MIT/AD-R&C/Post Doc/2012, dated 30.11.2012).

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Authors and Affiliations

  1. Department of Biomedical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India

    Eshwari Dathathri & Goutam Thakur

  2. Department of Electronics and Communication Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India

    Satyapriya Lal, Mohit Mittal & Shounak De

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  1. Eshwari Dathathri
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  2. Satyapriya Lal
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  3. Mohit Mittal
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  4. Goutam Thakur
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  5. Shounak De
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Correspondence to Goutam Thakur.

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Dathathri, E., Lal, S., Mittal, M. et al. Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery. Appl Nanosci 10, 371–377 (2020). https://doi.org/10.1007/s13204-019-01190-3

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  • DOI: https://doi.org/10.1007/s13204-019-01190-3

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