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Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging

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Abstract

Nanoparticles (NPs) are useful for radiotherapy. Currently, efforts are underway globally for the development of novel titanium dioxide NPs (TiO2-NPs) that exhibit both contrast effects and anti-tumor effects. In this study, the image contrast properties of TiO2-NPs were evaluated using a clinical magnetic resonance imaging (MRI) system and a clinical computed tomography (CT) scanner, as the use of TiO2-NPs as an anti-cancer agent has been reported in several reports. An obvious difference in visualization was observed between the control and TiO2-NP samples on T2-weighted images. These results suggest that TiO2 can potentially be used as a novel theranostic drug with radiosensitizing ability and radiological diagnostic ability, through modification of chemical groups on its surface, and as a component of drug delivery systems.

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Authors and Affiliations

  1. Division of Radiation Oncology, Kobe University Hospital, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Hiroaki Akasaka, Naritoshi Mukumoto & Ryohei Sasaki

  2. Division of Medical Radiations School Health and Biomedical Sciences, RMIT University, Plenty Road, Bundoora, VIC, 3083, Australia

    Masao Nakayama

  3. Division of Radiation Oncology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Tianyuan Wang, Ryuichi Yada, Yasuyuki Shimizu, Sachiko Inubushi & Ai Nakaoka

  4. Center for Radiology and Radiation Oncology, Kobe University Hospital, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Katsusuke Kyotani, Keisuke Okumura & Masanori Miyamoto

  5. Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkoudaicho, Nadaku, Kobe, Hyogo, 657-8501, Japan

    Kenta Morita, Yuya Nishimura & Chiaki Ogino

Authors
  1. Hiroaki Akasaka
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  2. Naritoshi Mukumoto
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  3. Masao Nakayama
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  4. Tianyuan Wang
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  8. Katsusuke Kyotani
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  9. Keisuke Okumura
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  11. Ai Nakaoka
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  12. Kenta Morita
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  13. Yuya Nishimura
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  14. Chiaki Ogino
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  15. Ryohei Sasaki
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Correspondence to Hiroaki Akasaka.

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Akasaka, H., Mukumoto, N., Nakayama, M. et al. Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging. Appl Nanosci 10, 3143–3148 (2020). https://doi.org/10.1007/s13204-019-01098-y

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  • DOI: https://doi.org/10.1007/s13204-019-01098-y

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