Applied Nanoscience

, Volume 8, Issue 5, pp 1133–1138 | Cite as

Gold nanoparticles tethered cinnamic acid: preparation, characterization, and cytotoxic effects on MCF-7 breast cancer cell lines

  • Karthika Subramanian
  • Kumar Ponnuchamy
Original Article


The main objective of the study is to tether citrate-stabilized gold nanoparticles (CS©GNPs) with cinnamic acid (CA) and evaluating them against MCF-7 breast cancer cells. To achieve CA~CS©GNPs, CS©GNPs prepared were blended with CA under controlled experimental conditions followed by high-throughput characterization. The result from the study demonstrates that positively charged hydrogen moiety present in O–H group of CA provides an opportunity for binding of CS©GNPs via hydrogen bonding evidenced by color change (ruby to light purple) and spectroscopic analysis (UV–visible and FT-IR spectroscopy). The size and shape of CA~CS©GNPs were not the same as CS©GNPs substantiated by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. At the end, cytotoxic and morphological assessment against MCF-7 breast cancer cells shows effective suppression of tumor cells and thereby promoting them as promising nanoscale drug delivery system in near future.


Cinnamic acid Citrate-stabilized gold nanoparticles FT-IR Electron microscopy Cytotoxic studies Breast cancer 



The work was supported by Early Career Research Award (ECR/2016/001456) from the Science Engineering and Research Board (SERB), New Delhi, India. We also thank SAIF AIIMS for providing transmission electron microscopic facilities.

Supplementary material

13204_2018_764_MOESM1_ESM.docx (55 kb)
Supplementary material 1 (DOCX 55 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and ManagementAlagappa UniversityKaraikudiIndia

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