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Gold nanoparticles tethered cinnamic acid: preparation, characterization, and cytotoxic effects on MCF-7 breast cancer cell lines

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Abstract

The main objective of the study is to tether citrate-stabilized gold nanoparticles (CS©GNPs) with cinnamic acid (CA) and evaluating them against MCF-7 breast cancer cells. To achieve CA~CS©GNPs, CS©GNPs prepared were blended with CA under controlled experimental conditions followed by high-throughput characterization. The result from the study demonstrates that positively charged hydrogen moiety present in O–H group of CA provides an opportunity for binding of CS©GNPs via hydrogen bonding evidenced by color change (ruby to light purple) and spectroscopic analysis (UV–visible and FT-IR spectroscopy). The size and shape of CA~CS©GNPs were not the same as CS©GNPs substantiated by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. At the end, cytotoxic and morphological assessment against MCF-7 breast cancer cells shows effective suppression of tumor cells and thereby promoting them as promising nanoscale drug delivery system in near future.

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Acknowledgements

The work was supported by Early Career Research Award (ECR/2016/001456) from the Science Engineering and Research Board (SERB), New Delhi, India. We also thank SAIF AIIMS for providing transmission electron microscopic facilities.

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Authors and Affiliations

  1. Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Science Block, Karaikudi, 630003, Tamil Nadu, India

    Karthika Subramanian & Kumar Ponnuchamy

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  1. Karthika Subramanian
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  2. Kumar Ponnuchamy
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Correspondence to Kumar Ponnuchamy.

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Subramanian, K., Ponnuchamy, K. Gold nanoparticles tethered cinnamic acid: preparation, characterization, and cytotoxic effects on MCF-7 breast cancer cell lines. Appl Nanosci 8, 1133–1138 (2018). https://doi.org/10.1007/s13204-018-0764-2

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  • DOI: https://doi.org/10.1007/s13204-018-0764-2

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