Gold nanoparticles tethered cinnamic acid: preparation, characterization, and cytotoxic effects on MCF-7 breast cancer cell lines
The main objective of the study is to tether citrate-stabilized gold nanoparticles (CS©GNPs) with cinnamic acid (CA) and evaluating them against MCF-7 breast cancer cells. To achieve CA~CS©GNPs, CS©GNPs prepared were blended with CA under controlled experimental conditions followed by high-throughput characterization. The result from the study demonstrates that positively charged hydrogen moiety present in O–H group of CA provides an opportunity for binding of CS©GNPs via hydrogen bonding evidenced by color change (ruby to light purple) and spectroscopic analysis (UV–visible and FT-IR spectroscopy). The size and shape of CA~CS©GNPs were not the same as CS©GNPs substantiated by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. At the end, cytotoxic and morphological assessment against MCF-7 breast cancer cells shows effective suppression of tumor cells and thereby promoting them as promising nanoscale drug delivery system in near future.
KeywordsCinnamic acid Citrate-stabilized gold nanoparticles FT-IR Electron microscopy Cytotoxic studies Breast cancer
The work was supported by Early Career Research Award (ECR/2016/001456) from the Science Engineering and Research Board (SERB), New Delhi, India. We also thank SAIF AIIMS for providing transmission electron microscopic facilities.
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