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Journal of Food Science and Technology

, Volume 55, Issue 5, pp 1675–1684 | Cite as

Identification and characterization of bioactive phenolic constituents, anti-proliferative, and anti-angiogenic activity of stem extracts of Basella alba and rubra

  • B. Ramesh Kumar
  • Apoorva Anupam
  • Padmavati Manchikanti
  • Arun Prabhu Rameshbabu
  • Swagata Dasgupta
  • Santanu Dhara
Original Article

Abstract

Basella is an important green leafy vegetable species of Chenopodiaceae family and is known for its medicinal properties. Hydroxy-benzoic acids, hydroxy-cinnamic acids and flavones groups were identified and characterized from the aqueous stem extracts of B. alba and B. rubra species. Higher values of phenolics as well as antioxidant activity were noted from B. alba species extracts. The evaluation of the cytoxicity of these extracts on A431 (epidermoid carcinoma), Hep G2 (hepatocellular carcinoma) and MG 63 (osteosarcoma) cells indicated anti-proliferative activity against all the cell lines. B. alba extract showed higher anti-proliferative activity (37.95–84.86%). Chick embryo chorioallantoic membrane (CAM) assay revealed inhibition of neo-vessels formation. Significant suppression was found with extracts of B. alba at 7 mg/ml compared to that of B. rubra. This is the first study to report the anti-angiogenic activity of Basella species. These studies indicate that Basella sps can be used as a source of natural antioxidants and can be of high significance in pharmaceutical and nutraceutical industries.

Keywords

Basella Phenolic compounds Antioxidants HPLC–ESI–MS Anti-angiogenesis Cytotoxicity 

Notes

Acknowledgements

The authors acknowledge the funding support provided by Ministry of Human Resource Development (MHRD) New Delhi, Government of India. We gratefully acknowledge the support from Department of Chemistry, IIT Kharagpur and School of Medicine Science and Technology, IIT Kharagpur.

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest.

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Copyright information

© Association of Food Scientists & Technologists (India) 2018

Authors and Affiliations

  • B. Ramesh Kumar
    • 1
  • Apoorva Anupam
    • 2
  • Padmavati Manchikanti
    • 1
  • Arun Prabhu Rameshbabu
    • 3
  • Swagata Dasgupta
    • 4
  • Santanu Dhara
    • 3
  1. 1.Plant Metabolic Pathway Laboratory, RGSOIPLIndian Institute of Technology KharagpurKharagpurIndia
  2. 2.School of BiosciencesIndian Institute of Technology KharagpurKharagpurIndia
  3. 3.School of Medical Science and TechnologyIndian Institute of Technology KharagpurKharagpurIndia
  4. 4.Department of ChemistryIndian Institute of Technology KharagpurKharagpurIndia

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