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Journal of Food Science and Technology

, Volume 53, Issue 1, pp 895–901 | Cite as

Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats

  • Arunaksharan Narayanankutty
  • Reshma K. Mukesh
  • Shabna K. Ayoob
  • Smitha K. Ramavarma
  • Indu M. Suseela
  • Jeksy J. Manalil
  • Balu T. Kuzhivelil
  • Achuthan C. RaghavamenonEmail author
Original Article

Abstract

Virgin Coconut Oil (VCO), extracted from fresh coconut kernel possess similar fatty acid composition to that of Copra Oil (CO), a product of dried kernel. Although CO forms the predominant dietary constituent in south India, VCO is being promoted for healthy life due to its constituent antioxidant molecules. High fructose containing CO is an established model for insulin resistance and steatohepatitis in rodents. In this study, replacement of CO with VCO in high fructose diet markedly improved the glucose metabolism and dyslipidemia. The animals fed VCO diet had only 17 % increase in blood glucose level compared to CO fed animals (46 %). Increased level of GSH and antioxidant enzyme activities in VCO fed rats indicate improved hepatic redox status. Reduced lipid peroxidation and carbonyl adducts in VCO fed rats well corroborate with the histopathological findings that hepatic damage and steatosis were comparatively reduced than the CO fed animals. These results suggest that VCO could be an efficient nutraceutical in preventing the development of diet induced insulin resistance and associated complications possibly through its antioxidant efficacy.

Keywords

Virgin coconut oil Copra oil High fructose diet Oxidative stress Insulin resistance Hepatosteatosis 

Abbreviations

VCO

Virgin Coconut Oil

CO

Copra Oil

HDLc

High Density Lipoprotein Cholesterol

GSH

Reduced Glutathione

GR

Glutathione Reductase

GPx

Glutathione Peroxidase

SOD

Super Oxide Dismutase

GST

Glutathione S Transferase

Notes

Acknowledgments

First author is thankful to the Council of Scientific and Industrial Research, India for the financial support in the form of Junior Research Fellowship (09/869 (0012)/2012-EMR-I). MJ Jeksy acknowledge the receipt of Junior research fellowship from INSPIRE, DST.

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Copyright information

© Association of Food Scientists & Technologists (India) 2015

Authors and Affiliations

  • Arunaksharan Narayanankutty
    • 1
  • Reshma K. Mukesh
    • 1
  • Shabna K. Ayoob
    • 1
  • Smitha K. Ramavarma
    • 1
  • Indu M. Suseela
    • 1
  • Jeksy J. Manalil
    • 1
  • Balu T. Kuzhivelil
    • 2
  • Achuthan C. Raghavamenon
    • 1
    • 3
    Email author return OK on get
  1. 1.Amala Cancer Research Centre, Amala Nagar P O(Recognized Centre of University of Calicut)ThrissurIndia
  2. 2.Applied Biochemistry and Biotechnology Laboratory, Department of Zoology, Christ College, IrinjalakkudaUniversity of CalicutKeralaIndia
  3. 3.Department of BiochemistryAmala Cancer Research CentreThrissurIndia

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