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In vitro meat production system: why and how?


Due to the nutritional importance and the sustained popularity of meat as a foodstuff, the livestock production sector has been expanding incessantly. This exponential growth of livestock meat sector poses a gigantic challenge to the sustainability of food production system. A new technological breakthrough is being contemplated to develop a substitute for livestock meat. The idea is to grow meat in a culture in the lab and manipulate its composition selectively. This paper aims to discuss the concept of In Vitro Meat production system, articulate the underlying technology and analyse the context of its implications, as proposed by several scientists and stakeholders. The challenges facing this emerging technology have also been discussed.

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  1. Alexandratos N, Bruinsma J (2012) World Agriculture Towards 2030/2050. ESA Working Paper no. 2012:12–03

    Google Scholar 

  2. Armstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15:617–631

    CAS  Article  Google Scholar 

  3. BBC News (2013) Accessed 7 August 2014.

  4. Bender A (1992) Meat and Meat Products in Human Nutrition in Developing Countries. FAO Food Nutr Pap 53. Rome: FAO.

  5. Benjaminson MA, Gilchriest JA, Lorenz M (2002) In vitro edible muscle protein production system (MPPS): stage 1, fish. Acta Astronautica 51:879–889

    CAS  Article  Google Scholar 

  6. Bhat, Fayaz (2011) Prospectus of cultured meat—advancing meat alternatives. J Food Sci Technol 48:125–140

  7. Bhat ZF, Bhat H (2011) Tissue engineered meat- future meat. J Stored Prod Postharvest Res 2:1–10

    Google Scholar 

  8. Birkenhead, Smith FE (1930) In: Earl of. The world in 2030 A.D, vol 1930. Hodder and Stoughton, London

  9. Boland T, Mironov V, Gutowska A, Roth E, Markwald R (2003) Cell and organ printing 2: fusion of cell aggregates in three- dimensional gels. Anat Rec 272A:497–502

    Article  Google Scholar 

  10. Charge S, Brack A, Hughes S (2002) Aging-related satellite cell differentiation defect occurs prematurely after ski-induced muscle hypertrophy. Am J Physiol Cell Physiol 283:C1228–C1241

    CAS  Article  Google Scholar 

  11. Churchill W (1932) Fifty years hence. In: Thoughts and Adventures London: Thornton Butterworth pp 24–27.

  12. CNN (2014) Accessed 7 August 2014.

  13. Coecke D et al (2005) Guidance on good cell culture practice. A Report of the second ECVAM task force on good cell culture practice. Altern Lab Anim 33:261–287

    CAS  Google Scholar 

  14. CSE India (2014) Accessed 3 August 2014.

  15. Datar I, Betti M (2010) Possibilities for an in vitro meat production system. Innovative Food Sci Emerg Technol 11:13–22

    CAS  Article  Google Scholar 

  16. DeGrazia D (1996) Taking animals seriously. Cambridge University Press, Moral life and moral status. Cambridge

    Book  Google Scholar 

  17. Delgado CL (2003) Rising consumption of meat and milk in developing countries has created a new food revolution. J Nutr 133:3907S–3910S

    CAS  Google Scholar 

  18. Dennis RG, Kosnik PE (2000) Excitability and isometric contractile properties of mammalian skeletal muscle constructs engineered in vitro. In Vitro Cell Dev Biol Anim 36:327

    CAS  Article  Google Scholar 

  19. Dwyer T, Hetzel BS (1980) A comparison of trends of coronary heart disease mortality in Australia, USA and England and wales with reference to three major risk factors – hypertension, cigarette smoking and diet. Int J Epidemiol 9:65–71

    CAS  Article  Google Scholar 

  20. Edelman P D (2003) In vitro meat production. Accessed 15 July 2014.

  21. Edelman PD, DC MCF, Mironov VA, Matheny JG (2005) In Vitro-cultured meat production. Tissue Eng 11:659–662

    CAS  Article  Google Scholar 

  22. Ford B J (2009) Culturing meat for the future: anti-death versus anti-life. In: Tandy C (ed) Death and anti-death, Volume 7. Ria University Press, California pp 55–80.

  23. Fox News (2009) Accessed 31 July 2014.

  24. Fox SI (1996) Human physiology, p 71. Brown Publishers, Wim C

    Google Scholar 

  25. FST Journal (2013) Accessed 10 August 2014.

  26. Garnet T (2010) Livestock, feed and food security. FCRN briefing paper,

  27. Goffman E (2012) Discovery guide: The Environmental Impact of Meat.

  28. Gold M (2004) The Global Benefits of Eating Less Meat. Compassion in World Farming Trust

  29. Guardian (2012) Would you eat lab-grown meat? tube-burger?INTCMP = SRCH.

  30. Hamburger junction, The Economist, 25-Feb-2012.

  31. Hopkins PD, Dacey a (2008) Vegetarian meat: could technology save animals and satisfy meat eaters? J Agric Environ Ethics 21(2008):579–596

    Article  Google Scholar 

  32. Houdebine LM (2009) Production of pharmaceutical proteins by transgenic animals. Comp Immunol Microbiol Infect Dis 32:107–121

    Article  Google Scholar 

  33. In Vitro Meat News (2014) Accessed 4 August 2014.

  34. Johnson R, Gibbs Jr C (1998) Creutzfeldt- jakob disease and related transmissible spongiform encephalopathies. N Engl J Me 339:1994–2004

    CAS  Article  Google Scholar 

  35. Kosnik PE, Dennis RG, Vandenburgh HH (2003) Tissue engineering skeletal muscle. In: In: guilak F, ed. Functional tissue engineering, vol 2003. Springer-Verlag, New York, pp. 377–392

  36. Langelaan MLP, Boonen KJM, Polak RB, Baaijens FPT, Post MJ, Schaf DWJ (2010) Meet the new meat: tissue engineered skeletal muscle. Trends Food Sci Technol 21:59–66

    CAS  Article  Google Scholar 

  37. Lesschen JP, van der Berg M, Westhoek HJ, Witzke HP, Oenema O (2011) Greenhouse gas emission profiles of European livestock sectors. Anim Feed Sci Technol 166–167:16–28

    Article  Google Scholar 

  38. Martin I, Wendt D, Heberer M (2004) The role of bioreactors in tissue engineering. Trends Biotechnol 22:80

    CAS  Article  Google Scholar 

  39. Mattick CS, Allenby BR (2010) Cultured meat: the systemic implications of an emerging technology. Technolo Soc Mag IEEE 29:22–30

    Article  Google Scholar 

  40. McMichael AJ, Powles JW, Butler CD, Uauy R (2007) Food, livestock production, energy, climate change, and health. Lancet 370:1253–1263

    Article  Google Scholar 

  41. Mottram DS (1999) Meat in volatile compounds in foods and beverages, (ed. H. Maarse), marcel Dekker. N Y 1991:107–117

    Google Scholar 

  42. Navigating the numbers (2014) accessed 7 Aug 2014.

  43. NDTV (2014) Accessed 3 August 2014.

  44. New Harvest (2014):

  45. Ohira Y, Yoshinaga T, Nomura T, Kawano F, Ishihara A, Nonaka I, Roy R, Edgerton V (2002) Gravitational unloading effects on muscle fiber size, phenotype and myonuclear number. Adv Space Res 30:777–781

    CAS  Article  Google Scholar 

  46. Post MJ (2012) Cultured meat from stem cells: challenges and prospects. Meat Sci 92:297–301

    Article  Google Scholar 

  47. Powell CA, Smiley BL, Mills J, Vandenburgh HH (2002) Mechanical stimulation improves tissue-engineered human skeletal muscle. Am J Physiol Cell Physiol 283:C1557

    CAS  Article  Google Scholar 

  48. Rosegrant M, Leach N, Gerpacio R (1999) Alternative futures for world cereal and meat consumption. Proc Nutr Soc 58:219–234

    CAS  Article  Google Scholar 

  49. Sanders T (1999) The nutritional adequacy of plant-based diets. Proc Nutr Soc 58:265–269

    CAS  Article  Google Scholar 

  50. Speedy AW (2003) Global production and consumption of animal source foods. J Nutrition 133:4048S–4053S

    CAS  Google Scholar 

  51. Stephens N (2013) Growing meat in laboratories: the promise, ontology, and ethical boundary-work of using muscle cells to make food. Configurations 21:159–181

    Article  Google Scholar 

  52. Thorogood M, Mann J, Appleby P, McPherson K (1994) Risk of death from cancer and ischaemic heart disease in meat and non-meat eaters. In BMJ 308:6945

    Article  Google Scholar 

  53. Tuomisto H L and Roy A G (2012) Could cultured meat reduce environmental impact of agriculture in Europe? 8th international conference on LCA in the Agri-food sector, Rennes, France, 2–4 October 2012.

  54. Tuomisto HL, Teixeira de Mattos MJ (2011) Environmental Impacts of Cultured Meat Production. Environ Sci Technol. doi:10.1021/es200130u

    Google Scholar 

  55. UNEP GEAS (2012) Accessed 19 September 2014.

  56. Van Eelen W F, van Kooten W J and Westerhof W (1999) WO/1999/031223: industrial production of meat from in vitro cell cultures. Patent Description wo = 1999031223. Accessed 17 March 2013.

  57. Voedingscentrum (2003) Accessed 12 July 2014.

  58. Walker P, Rhubart-Berg P, McKenzie S, Kelling K, Lawrence RS (2005) Public health implications of meat production and consumption. Public Health Nutr 8:348–356

    Article  Google Scholar 

  59. Weele CV, Driessen C (2013) Emerging profiles for cultured meat; ethics through and as design. Animals 3:647–662

    Article  Google Scholar 

  60. Welin S (2013) Introducing the new meat. Problems and prospects. Nordic J Applied Ethics 7:24–37

    Google Scholar 

  61. Welin S, Weele CV (2012) Cultured meat: will it separate us from nature? Climate Change Sustain Dev 1:348–351

    Article  Google Scholar 

  62. Williams J (2012) Meat derived from stem cells: how, what and why. Accessed 15 July 2014.

  63. Wolfson W (2002) Raising the steaks. New Sci 176:60–63

    Google Scholar 

  64. World Health Organization (2009) World health statistics. WHO, Geneva

    Google Scholar 

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Conflict of interest

It is declared that there is no conflict of interest between both the others.

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Correspondence to Shruti Sharma.

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The authors confirm the work to be original and that it has not been previously submitted to any other journal for consideration. All the authors are aware of the submission of this manuscript to JFST.

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Sharma, S., Thind, S.S. & Kaur, A. In vitro meat production system: why and how?. J Food Sci Technol 52, 7599–7607 (2015).

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  • Cultured meat
  • IMPS
  • Stem cells
  • GHG emissions
  • Consumer acceptance