Journal of Food Science and Technology

, Volume 50, Issue 6, pp 1035–1046 | Cite as

Genetically modified foods: safety, risks and public concerns—a review

  • A. S. BawaEmail author
  • K. R. Anilakumar
Invited Review


Genetic modification is a special set of gene technology that alters the genetic machinery of such living organisms as animals, plants or microorganisms. Combining genes from different organisms is known as recombinant DNA technology and the resulting organism is said to be ‘Genetically modified (GM)’, ‘Genetically engineered’ or ‘Transgenic’. The principal transgenic crops grown commercially in field are herbicide and insecticide resistant soybeans, corn, cotton and canola. Other crops grown commercially and/or field-tested are sweet potato resistant to a virus that could destroy most of the African harvest, rice with increased iron and vitamins that may alleviate chronic malnutrition in Asian countries and a variety of plants that are able to survive weather extremes. There are bananas that produce human vaccines against infectious diseases such as hepatitis B, fish that mature more quickly, fruit and nut trees that yield years earlier and plants that produce new plastics with unique properties. Technologies for genetically modifying foods offer dramatic promise for meeting some areas of greatest challenge for the 21st century. Like all new technologies, they also pose some risks, both known and unknown. Controversies and public concern surrounding GM foods and crops commonly focus on human and environmental safety, labelling and consumer choice, intellectual property rights, ethics, food security, poverty reduction and environmental conservation. With this new technology on gene manipulation what are the risks of “tampering with Mother Nature”?, what effects will this have on the environment?, what are the health concerns that consumers should be aware of? and is recombinant technology really beneficial? This review will also address some major concerns about the safety, environmental and ecological risks and health hazards involved with GM foods and recombinant technology.


Genetically modified foods Genetically engineered foods Transgenic foods Food safety Allergenic foods Public concerns 


  1. Allison S, Palma PM (1997) Commercialization of transgenic plants: potential ecological risks. BioScience 47:86–96CrossRefGoogle Scholar
  2. Ballari VR, Martin A, Gowda LR (2012) Detection and identification of genetically modified EE-1 brinjal (Solanum melongena) by single, multiplex and SYBR® real-time PCR. J Sci Food Agric. doi: 10.1002/jsfa.5764, Published online 22 June 2012
  3. Beagle JM, Apgar GA, Jones KL, Griswold KE, Radcliffe JS, Qiu X, Lightfoot DA, Iqbal MJ (2006) The digestive fate of Escherichia coli glutamate dehydrogenase deoxyribonucleic acid from transgenic corn in diets fed to weanling pigs. J Anim Sci 84(3):597–607Google Scholar
  4. Berberich SA, Ream JE, Jackson TL, Wood R, Stipanovic R, Harvey P, Patzer S, Fuchs RL (1996) The composition of insect-protected cottonseed is equivalent to that of conventional cottonseed. J Agric Food Chem 44:365–371CrossRefGoogle Scholar
  5. Bernstein IL, Bernstein JA, Miller M, Tierzieva S, Bernstein DI, Lummus Z, Selgrade MK, Doerfler DL, Seligy VL (1999) Immune responses in farm workers after exposure to Bacillus thuringiensis pesticides. Environ Health Perspect 107:575–582CrossRefGoogle Scholar
  6. Brake J, Vlachos D (1998) Evaluation of transgenic Event 176 “Bt” corn in broiler chicken. Poult Sci 77:648–653Google Scholar
  7. Brian H (1999) Unintended effects of Bt crops. World Watch 12:9–10Google Scholar
  8. Brigulla M, Wackernagel W (2010) Molecular aspects of gene transfer and foreign DNA acquisition in prokaryotes with regard to safety issues. Appl Microbiol Biotechnol 86(4):1027–1041CrossRefGoogle Scholar
  9. Burks AW, Fuchs RL (1995) Assessment of the endogenous allergens in glyphosate-tolerant and commercial soybean varieties. J Allergy Clin Immunol 96:1008–1010CrossRefGoogle Scholar
  10. Butler T, Reichhardt T (1999) Long-term effect of GM crops serves up food for thought. Nature 398(6729):651–653CrossRefGoogle Scholar
  11. Cellini F, Chesson A, Colquhoun I, Constable A, Davies HV, Engel KH, Gatehouse AMR, Karenlampi S, Kok EJ, Leguay JJ, Lehasranta S, Noteborn HPJM, Pedersen J, Smith M (2004) Unintended effects and their detection in genetically modified crops. Food Chem Toxicol 42:1089–1125CrossRefGoogle Scholar
  12. Chapman MD (2008) Allergen nomenclature. In: Lockey RF, Dennis Ledford K (eds) Allergens and allergen immunotherapy, 4th edn. Informa Healthcare, New York, pp 47–58Google Scholar
  13. Clive J (1996) Global review of the field testing and commercialization of transgenic plants: 1986 to 1995. The International Service for the Acquisition of Agri-biotech Applications. Retrieved on 17 July 2010
  14. Clive J (2011) Global status of commercialized Biotech/GM crops. ISAAA Briefs 43. International Service for the Acquisition of Agri-biotech Applications, IthacaGoogle Scholar
  15. Conner AJ, Jacobs JME (1999) Genetic engineering of crops as potential source of genetic hazard in the human diet. Mutat Res Genet Toxicol Environ Mutagen 443:223–234CrossRefGoogle Scholar
  16. Crevel RWR, Lerkhof MAT, Koning MMG (2000) Allergenicity of refined vegetable oils. Food Chem Toxicol 38(4):385–393CrossRefGoogle Scholar
  17. Deisingh AK, Badrie N (2005) Detection approaches for genetically modified organisms in foods. Food Res Int 38:639–649CrossRefGoogle Scholar
  18. Domingo JL (2000) Health risks of genetically modified foods: many opinions but few data. Science 288:1748–1749CrossRefGoogle Scholar
  19. Ewen SWB, Pusztai A (1999) Effects of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet 354:1353–1354CrossRefGoogle Scholar
  20. Fares NH, El-Sayed AK (1998) Fine structural changes in the ileum of mice fed on delta-endotoxin-treated potatoes and transgenic potatoes. Nat Toxins 6:219–233CrossRefGoogle Scholar
  21. Frewer LI, Salter B (2002) Public attitudes, scientific advice and the politics of regulatory policy the case of BSE. Sci Public Policy 29:137–145CrossRefGoogle Scholar
  22. Gerhard F, Andrew C, Karen A (2005) Animal nutrition with feeds from genetically modified plants. Arch Anim Nutr 59:1–40CrossRefGoogle Scholar
  23. Guertler P, Paul V, Albrech C, Meyer HH (2009) Sensitive and highly specific quantitative real-time PCR and ELISA for recording a potential transfer of novel DNA and Cry1Ab protein from feed into bovine milk. Anal Bioanal Chem 393:1629–1638CrossRefGoogle Scholar
  24. Hamer H, Scuse T (2010) National Agricultural Statistics Service (NASS), Agricultural Statistics Board, US Department of Agriculture. Acreage report, NYGoogle Scholar
  25. Hammond BG, Vicini JL, Hartnell GF, Naylor MW, Knight CD, Robinson EH, Fuchs RL, Padgette SR (1996) The feeding value of soybeans fed to rats, chickens, catfish and dairy cattle is not altered by genetic incorporation of glyphosate tolerance. J Nutr 126:717–727Google Scholar
  26. Hamstra A (1998) Public opinion about Biotechnology. A survey of surveys. European Federation of Biotechnology, The HagueGoogle Scholar
  27. Harrison LA, Bailey MR, Naylor MW, Ream JE, Hammond BG, Nida DL, Burnette BL, Nickson TE, Mitsky TA, Taylor ML, Fuchs RL, Padgette SR (1996) The expressed protein in glyphosate-tolerant soybean, 5-enolpyruvylshikimate-3-phosphate synthase from Agrobacterium sp. strain CP4, is rapidly digested in vitro and is not toxic to acutely gavaged mice. J Nutr 126:728–740Google Scholar
  28. Hashimoto W, Momma K, Katsube T, Ohkawa Y, Ishige T, Kito M, Utsumi S, Murata K (1999a) Safety assessment of genetically engineered potatoes with designed soybean glycinin: compositional analyses of the potato tubers and digestibility of the newly expressed protein in transgenic potatoes. J Sci Food Agric 79:1607–1612CrossRefGoogle Scholar
  29. Hashimoto W, Momma K, Yoon HJ, Ozawa S, Ohkawa Y, Ishige T, Kito M, Utsumi S, Murata K (1999b) Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats. Biosci Biotechnol Biochem 63:1942–1946CrossRefGoogle Scholar
  30. IRDC (1998) Alliance for biointegrity. including Calgene FLAVR SAVR™ tomato report, pp 1–604; International Research and Development Corp. first test report, pp 1736–1738; Conclusions of the expert panel regarding the safety of the FLAVR SAVR™ tomato, ENVIRON, Arlington VA, USA pp 2355–2382; Four week oral (intubation) toxicity study in rats by IRDC, pp 2895–3000
  31. Ivanciuc O, Schein CH, Braun W (2003) SDAP: database and computational tools for allergenic proteins. Nucleic Acids Res 31:359–362CrossRefGoogle Scholar
  32. Joana C, Isabel M, Joana SA, Oliveira MBPP (2010) Monitoring genetically modified soybean along the industrial soybean oil extraction and refining processes by polymerase chain reaction techniques. Food Res Int 43:301–306. doi: 10.1016/j.foodres.2009.10.003 CrossRefGoogle Scholar
  33. Johnson SR (2008) Quantification of the impacts on US Agriculture of Biotechnology-Derived Crops Planted in 2006. National Centre for Food and Agricultural Policy, Washington DCGoogle Scholar
  34. Kleter GA, Peijnenburg AACM (2002) Screening of transgenic proteins expressed in transgenic food crops for the presence of short amino acid sequences identical to potential, IgE-binding linear epitopes of allergens. BMC Struct Biol 2:8–19, CrossRefGoogle Scholar
  35. Kumar GBS, Ganapathi TR, Revathi CJ, Srinivas L, Bapat VA (2005) Expression of hepatitis B surface antigen in transgenic banana plants. Planta 222:484–493CrossRefGoogle Scholar
  36. Lack G (2002) Clinical risk assessment of GM foods. Toxicol Lett 127:337–340CrossRefGoogle Scholar
  37. La Mura M, Allnutt TR, Greenland A, Mackay LD (2011) Application of QUIZ for GM quantification in food. Food Chem 125:1340–1344CrossRefGoogle Scholar
  38. Lappe MA, Bailey EB, Childress C, Setchell KDR (1999) Alterations in clinically important phytoestrogens in genetically modified, herbicide-tolerant soybeans. J Med Food 1:241–245CrossRefGoogle Scholar
  39. Lassen J, Allansdottir A, Liakoupulos M, Olsson A, Mortensen AT (2002) Testing times: the reception of round-up ready soya in Europe. In: Bauer M, Gaskell G (eds) Biotechnology—the making of a global controversy. Cambridge University Press, Cambridge, pp 279–312Google Scholar
  40. Louda SM (1999) Insect Limitation of weedy plants and its ecological implications. In: Traynor PL, Westwood J H (eds) Proceedings of a workshop on: ecological effects of pest resistance genes in managed ecosystems. Information Systems for Biotechnology. Blacksburg, Virginia, pp 43–48,
  41. Mari A, Riccioli D (2004) The allergome web site—a database of allergenic molecules. Aim, structure, and data of a web-based resource. J Allergy Clin Immunol 113:S301Google Scholar
  42. Martinez-Poveda A, Molla-Bauza MB, Gomis FJC, Martinez LMC (2009) Consumer-perceived risk model for the introduction of genetically modified food in Spain. Food Policy 34:519–528CrossRefGoogle Scholar
  43. Maryanski JH (1997) Bioengineered foods: will they cause allergic reactions? U.S. Food and Drug Administration (FDA)/Centre for Food Safety and Applied Nutrition (CFSAN), NYGoogle Scholar
  44. Metcalf DD, Astwood JD, Townsend R, Sampson HA, Taylor SL, Fuchs RL (1996) Assessment of the allergenic potential of foods derived from genetically engineered crop plants. In: Crit Rev Food Sci Nutr 36(S):S165–S186. CRC, Boca RatonGoogle Scholar
  45. Miles S, Frewer LI (2001) Investigating specific concerns about different food hazards—higher and lower order attributes. Food Qual Prefer 12:47–61CrossRefGoogle Scholar
  46. Miraglia M, Berdal K, Brera C, Corbisier P, Holst-jensen A, Kok E, Marvin H, Schimmel H, Rentsch J, van Rie J, Zagon J (2004) Detection and traceability of genetically modified organisms in the food production chain. Food Chem Toxicol 42:1157–1180CrossRefGoogle Scholar
  47. Momma K, Hashimoto W, Ozawa S, Kawai S, Katsube T, Takaiwa F, Kito M, Utsumi S, Murata K (1999) Quality and safety evaluation of genetically engineered rice with soybean glycinin: analyses of the grain composition and digestibility of glycinin in transgenic rice. Biosci Biotechnol Biochem 63:314–318CrossRefGoogle Scholar
  48. Nakamura R, Matsuda T (1996) Rice allergenic protein and molecular-genetic approach for hypoallergenic rice. Biosci Biotechnol Biochem 60:1215–1221CrossRefGoogle Scholar
  49. Netherwood T (2004) Assessing the survival of transgenic plant DNA in the human gastrointestinal tract. Nat Biotechnol 22:204–209CrossRefGoogle Scholar
  50. Nordlee JA (1996) Identification of Brazil-Nut allergen in transgenic soybeans. New Engl J Med 334:688–692CrossRefGoogle Scholar
  51. Nordlee JA, Taylor SL, Townsend JA, Thomas LA (1996) Identification of a Brazil nut allergen in transgenic soybean. New Engl J Med 334:688–692CrossRefGoogle Scholar
  52. Noteborn HPJM, Bienenmann-Ploum ME, van den Berg JHJ, Alink GM, Zolla L, Raynaerts A, Pensa M, Kuiper HA (1995) Safety assessment of the Bacillus thuringiensis insecticidal crystal protein CRYIA(b) expressed in transgenic tomatoes. In: Engel KH, Takeoka GR, Teranishi R (eds) ACS Symp series 605 Genetically modified foods—safety issues. American Chemical Society, Washington, D.C, pp 135–147, Chapter 12Google Scholar
  53. Novak WK, Haslberger AG (2000) Substantial equivalence of antinutrients and inherent plant toxins in genetically modified novel foods. Food Chem Toxicol 38:473–483CrossRefGoogle Scholar
  54. O’Neil C, Reese G, Lehrer SB (1998) Allergenic potential of recombinant food proteins. Allergy Clin Immunol Int 10:5–9Google Scholar
  55. Padgette SR, Taylor NB, Nida DL, Bailey MR, MacDonald J, Holden LR, Fuchs RL (1996) The composition of glyphosate-tolerant soybean seeds is equivalent to that of conventional soybeans. J Nutr 126:702–716Google Scholar
  56. Pusztai A (2001) Safety tests on commercial crops. American Institute of Biological Sciences., viewed 2 March 2010
  57. Pusztai A, Ewen SWB, Grant G, Peumans WJ, van Damme EJM, Rubio L, Bardocz S (1990) Relationship between survival and binding of plant lectins during small intestinal passage and their effectiveness as growth factors. Digestion 46(suppl 2):308–316CrossRefGoogle Scholar
  58. Pusztai A, Grant G, Bardocz S, Alonso R, Chrispeels MJ, Schroeder HE, Tabe LM, Higgins TJV (1999) Expression of the insecticidal bean alpha-amylase inhibitor transgene has minimal detrimental effect on the nutritional value of peas fed to rats at 30 % of the diet. J Nutr 129:1597–1603Google Scholar
  59. Redenbaugh K, Hiatt W, Martineau B, Kramer M, Sheehy R, Sanders R, Houck C, Emlay D (1992) Safety assessment of genetically engineered fruits and vegetables: a case study of the Flavr Savr Tomato. CRC Press, Boca RatonGoogle Scholar
  60. Sahai S (2003) Genetically modified crops: issues for India. Fin Agric 35:7–11Google Scholar
  61. Snell C, Bernheim A, Bergé J-B, Kuntz M, Pascal G, Paris A, Agnès ER (2012) Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food Chem Toxicol 50:1134–1148CrossRefGoogle Scholar
  62. Steinbrecher RA (1996) From green to gene evolution: the environmental risks of genetically engineered crops. Ecologist 26:273–281Google Scholar
  63. Streit L (2001) Association of the Brazil nut protein gene and Kunitz trypsin inhibitor alleles with soybean protease inhibitor activity and agronomic traits. Crop Sci 41:1757–1760CrossRefGoogle Scholar
  64. Taylor NB, Fuchs RL, MacDonald J, Shariff AB, Padgette SR (1999) Compositional analysis of glyphosate-tolerant soybeans treated with glyphosate. J Agric Food Chem 47:4469–4473CrossRefGoogle Scholar
  65. Teshima R, Akiyama H, Okunuki H, Sakushima J-i, Goda Y, Onodera H, Sawada J-i, Toyoda M (2000) Effect of GM and non-GM soybeans on the immune system of BN rats and B10A mice. J Food Hyg Soc Jpn 41:188–193CrossRefGoogle Scholar
  66. Tsourgiannis L, Karasavvoglou A, Florou G (2011) Consumers’ attitudes towards GM free products in a European region. The case of the Prefecture of Drama-Kavala-Xanthi in Greece. Appetite 57:448–458CrossRefGoogle Scholar
  67. van Beilen JB, Yves P (2008) Harnessing plant biomass for biofuels and biomaterials: production of renewable polymers from crop plants. Plant J 54(4):684–701CrossRefGoogle Scholar
  68. Vazquez-Padron RI, Moreno-Fierros L, Neri-Bazan L, Martinez-Gil AF, de la Riva GA, Lopez-Revilla R (2000) Characterization of the mucosal and sytemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice. Braz J Med Biol Res 33:147–155CrossRefGoogle Scholar
  69. Vijayakumar KR, Martin A, Gowda LR, Prakash V (2009) Detection of genetically modified soya and maize: impact of heat processing. Food Chem 117:514–521CrossRefGoogle Scholar
  70. Xiumin W, Da T, Qingfeng G, Fang T, Jianhua W (2012) Detection of Roundup Ready soybean by loop-mediated isothermal amplification combined with a lateral-flow dipstick. Food Control 29:213–220. doi: 10.1016/j.foodcont.2012.06.007, ISSN: 0956-7135Google Scholar

Copyright information

© Association of Food Scientists & Technologists (India) 2012

Authors and Affiliations

  1. 1.Defence Food Research LaboratoryMysoreIndia

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