Abstract
Lipoleiomyosarcoma is a malignant tumor of both mesenchymal and smooth muscle origin. Lipoleiomyosarcoma is a very rare type of retroperitoneal sarcoma, which by itself is a rare type of soft tissue sarcoma. Lipoleiomyosarcoma is a very rare subtype of liposarcoma, which is the most common type of retroperitoneal sarcoma. To our best review of available literature, this was the first case of lipoleiomyosarcoma presenting as a massive retroperitoneal mass of size 50 × 50 × 30 cm, managed with multi-visceral R0 resection. The computed tomography of the abdomen showed a massive fat density lesion with internal soft density lesions and internal calcifications. Multivisceral resection was planned and executed and achieved R0 resection. We suggest that lipoleiomyosarcoma should be included in differential diagnosis of retroperitoneal tumors, and multi-visceral R0 resection should be considered as an option for lipoleiomyosarcoma, as these tumors have very good prognosis with R0 resection.
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References
Folpe AL, Weiss SW (2002) Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiation. Am J Surg Pathol 26(6):742–749. https://doi.org/10.1097/00000478-200206000-00007
Pisters PWT, Weiss M, Maki R. Soft-Tissue Sarcomas. https://pdfs.semanticscholar.org/61b9/cfc10b9c36dbb931aa95e3fea0b81d9b5018.pdf
Tong JJ, Li XJ, Li GX, Qian GQ (2018) Lipoleiomyosarcoma of the posterior mediastinum. QJM 111(3):191–192. https://doi.org/10.1093/qjmed/hcx256
Khan WF, Rathore YS, Aduri RS, Mridha AR (2019) Lipoleiomyosarcoma of spermatic cord: an unusual presentation. BMJ Case Rep 12(8):e228952. https://doi.org/10.1136/bcr-2018-228952
Evans HL (1990) Smooth muscle in atypical lipomatous tumors. A report of three cases. Am J Surg Pathol 14(8):714–8. https://doi.org/10.1097/00000478-199008000-00002
Van Roggen JF, Hogendoorn PC (2000) Soft tissue tumours of the retroperitoneum. Sarcoma 4(1–2):17–26. https://doi.org/10.1155/S1357714X00000049
Cormier JN, Pollock RE (2004) Soft tissue sarcomas. CA Cancer J Clin 54(2):94–109. https://doi.org/10.3322/canjclin.54.2.94
Choi JH, Ro JY (2020) Retroperitoneal sarcomas: an update on the diagnostic pathology approach. Diagnostics (Basel) 10(9):642. https://doi.org/10.3390/diagnostics10090642
Tallini G, Erlandson RA, Brennan MF, Woodruff JM (1993) Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. Am J Surg Pathol 17(6):546–556. https://doi.org/10.1097/00000478-199306000-00002
Suster S, Wong TY, Moran CA (1993) Sarcomas with combined features of liposarcoma and leiomyosarcoma. Study of two cases of an unusual soft-tissue tumor showing dual lineage differentiation. Am J Surg Pathol 17(9):905–11. https://doi.org/10.1097/00000478-199309000-00006
Evans HL, Khurana KK, Kemp BL, Ayala AG (1994) Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol 18(11):1150–1157. https://doi.org/10.1097/00000478-199411000-00009
Gómez-Román JJ, Val-Bernal JF (1997) Lipoleiomyosarcoma of the mediastinum. Pathology 29(4):428–430. https://doi.org/10.1080/00313029700169475
Jha A, Sayami G, Adhikari D (2007) Lipoleiomyosarcoma an extremely unusual sarcoma of uterus: a case report. Nepal J Obstetrics Gynaecol 2(1):67–70. https://doi.org/10.3126/njog.v2i1.1482
Hwang EJ, Lim MC, Kim EN, Kwon Y, Hong EK, Jung DC et al (2010) Lipoleiomyosarcoma of the uterus: a case report and review. Korean J Obstetrics Gynecol 53(11):1019–1023. https://doi.org/10.5468/kjog.2010.53.11.1019
Lee HP, Tseng HH, Hsieh PP, Shih TF (2012) Uterine lipoleiomyosarcoma: report of 2 cases and review of the literature. Int J Gynecol Pathol 31(4):358. https://doi.org/10.1097/PGP.0b013e31823f841f
Drapeau-Zgoralski V, Doyon J, Berthiaume MJ, Mottard S (2017) Uterine lipoleiomyosarcoma: complete medullary compression as presentation of a solitary metastasis. Gynecol Oncol Rep 25(21):7–9. https://doi.org/10.1016/j.gore.2017.04.006
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Aaron, D.J., Warikoo, V., Salunke, A. et al. Lipoleiomyosarcoma Presenting as Massive Retroperitoneal Mass: An Unusual Soft Tissue Tumor of Abdomen and its Review of Literature. Indian J Surg Oncol 15 (Suppl 3), 418–422 (2024). https://doi.org/10.1007/s13193-024-01989-9
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DOI: https://doi.org/10.1007/s13193-024-01989-9