Abstract
Malignant melanoma is a formidable tumor originating from melanocytes of neural crest origin, found in various anatomical locations, primarily in the skin, followed by the eyes and mucosal membranes. This tumor stands out due to its remarkable phenotypic diversity. Transdifferentiation, the process of differentiation into cell lineages other than the one from which the tumor originated, and phenotypic plasticity, characterized by changes in behavior, morphology, and physiology in response to different environmental conditions, can make melanoma a diagnostic conundrum for unwary pathologists. In this case report, we present a challenging case of melanoma with cartilaginous transdifferentiation to shed light on its clinical, pathological, and molecular aspects.
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References
Castro-Pérez E, Singh M, Sadangi S, Mela-Sánchez C, Setaluri V (2023) Connecting the dots: Melanoma cell of origin, tumor cell plasticity, trans-differentiation, and drug resistance. Pigment Cell Melanoma Res 36(5):330–347. https://doi.org/10.1111/pcmr.13092
Jopling C, Boue S, Izpisua Belmonte JC (2011) Dedifferentiation, transdifferentiation and reprogramming three routes to regeneration. Nat Rev Mol Cell Biol 12:79–89
Xu L, Zhang K, Wang J (2014) Exploring the mechanisms of differentiation, dedifferentiation, reprogramming and transdifferentiation. PLoS ONE 9(8):e105216
Kilsdonk MJ, Romeijn TR, Kelder W, van Kempen LC, Diercks GF (2020) Angiosarcomatous transdifferentiation of metastatic melanoma. J Cutan Pathol 47(12):1211–1214
Berro J, Abdul Halim N, Khaled C, Assi HI (2019) Malignant melanoma with metaplastic cartilaginous transdifferentiation: a case report. J Cutan Pathol 46(12):935–994
Banerjee SS, Eyden B (2008) Divergent differentiation in malignant melanomas: a review. Histopathology 52:119–129
Banerjee SS, Harris M (2000) Morphological and immunophenotypic variations in malignant melanoma. Histopathology 36(5):387–402
Magro CM, Crowson AN, Mihm MC (2006) Unusual variants of malignant melanoma. Mod Pathol 19(suppl 2):S41–S70
Parente JD, Labareda JMPS, Bartolo EAFLF, Santos MFSPF, do Vale EMS (2013) Cartilaginous melanoma: case report and review of the literature. An Bras Dernatol 88(3):403–407
WHO Classification of Tumours Editorial Board (2020) Soft tissue and bone tumours. International Agency for Research on Cancer, Lyon, France. https://tumourclassification.iarc.who.int/chapters/33. Accessed 2024/01/01
Movva et al (2015) Multi-platform profiling of over 2000 sarcomas: identification of biomarkers and novel therapeutic targets. Oncotarget 6(14):12234–12247
Acknowledgements
We extend our gratitude to the patient’s family, our surgical and pathology colleagues, and molecular scientists whose contributions were instrumental in reaching the final diagnosis.
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Gowda, V.V., Vijayanarasimha, D., Srihari, S.M. et al. Cartilaginous Transdifferentiation in Melanoma: A Diagnostic Challenge. Indian J Surg Oncol (2024). https://doi.org/10.1007/s13193-024-01930-0
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DOI: https://doi.org/10.1007/s13193-024-01930-0