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Phyllodes Tumors of the Breast—Experience in a Tertiary Care Center

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Abstract

Phyllodes tumors (PTs) are rare neoplasms of the breast that are a challenge in clinical practice. Though mostly benign, they are notorious for local recurrence, requiring adjuvant treatments. This study was planned to report the clinicopathological features and outcomes of patients with PT treated at our center. Details of all patients who underwent surgery for PT in the last 6 years (December 2017–December 2023) were obtained from our prospectively maintained database. The demographic, clinical, radiological, pathological, and follow-up details were recorded and analyzed. Statistical analyses were carried out with Jamovi version 2.3.18. Out of 61 suspected PTs by triple assessment, 9 were excluded due to a non-phyllodes diagnosis on histopathology. We included 52 women with a mean age of 38.2 ± 11.0 years, most of whom were premenopausal (57.7%). BI-RADS 4 was the most common finding on radiological assessment (65.4%). Core needle biopsy (CNB) was the most frequently employed modality for histological diagnosis preoperatively (65.4% of cases). Wide local excisions (WLE) and mastectomies were done in 63.5% and 36.5% of patients, respectively. Benign, borderline, and malignant phyllodes constituted 67.3%, 15.4%, and 17.3% of tumors, respectively. Patients undergoing breast conservation surgery (BCS) had a significantly smaller mean tumor diameter than those who underwent a mastectomy (p < 0.001). Overall, the margin positivity rate was 34.6%. Patients undergoing mastectomy developed more local recurrence compared to WLE, although the difference was not significant (p = 0.400). The outcome following surgical excisions of large PTs in terms of margin positivity and local recurrence is the same, irrespective of whether BCS or mastectomy is done. A negative pathological margin width of > 1 mm appears acceptable. Malignant phyllodes with positive margins are associated with a higher rate of recurrence but positive margins in patients with other subtypes may not translate into recurrence, at least in the short term.

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Authors and Affiliations

  1. Department of General Surgery, All India Institute of Medical Sciences, Patna, Bihar, 801507, India

    Atul Anand, Deepti Bhatt & Prashant Kumar Singh

  2. Department of General Surgery (Endocrine Surgery), All India Institute of Medical Sciences, Phulwarisharif, Patna, Bihar, 801507, India

    Chandan Kumar Jha

  3. Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Bihar, 801507, India

    Upasna Sinha

  4. Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, 801507, India

    Greeshma Gopinath & Punam Prasad Bhadani

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  1. Atul Anand
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Correspondence to Chandan Kumar Jha.

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Anand, A., Jha, C.K., Sinha, U. et al. Phyllodes Tumors of the Breast—Experience in a Tertiary Care Center. Indian J Surg Oncol (2024). https://doi.org/10.1007/s13193-024-01926-w

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