Skip to main content

Advertisement

SpringerLink
Log in

Clinico-Demographic Profile Of Soft Tissue Sarcoma- 5 Year Experience From A Tertiary Care Centre Of Eastern India

  • Original Article
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

Soft tissue sarcomas (STS) are a diverse group of malignant mesenchymal neoplasm.But, due to their low prevalence, very little data is available worldwide as well as in India regarding their clinico-epidemiological pattern.In this study we analysed the clinico-demographic profile of STS patients attending a tertiary care centre of Eastern India over the last 5 years. We analyzed the prospectively maintained database of a tertiary care centre of West Bengal in Eastern India, and collected the data regarding the demography, clinical profile, pathology and treatment of STS patients who attended our OPD between 2017–2021. The objective was to assess the demographic and clinical data of STS patients of Eastern India and compare it with those of the reported literature from rest of the country as well as outside world. Most of the cases (27%) were between 41–50 years of age group with a slight male predominance (Male: Female = 1.01:1). Spindle cell sarcoma was the most common (24.3%) histology followed by undifferentiated pleomorphic sarcoma (15%) and extremities were the most common site of involvement (47.7%). 71% patients presented with stage III and advanced disease.81% patients underwent radical surgery,14% patient received neo-adjuvant and 60% received adjuvant radiotherapy.91% patients received systemic chemotherapy. To conclude, this study is one of its first from Eastern India and will act as a stepping stone for future studies concentrating on clinico-epidemiological profile, early diagnosis and treatment of STS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig.1
Fig. 2

Similar content being viewed by others

Data Availability

All study data are available with the authors and it can be provided if required.

References

  1. Lahat G, Lazar A, Lev D (2008) Sarcoma epidemiology and etiology: potential environmental and genetic factors. Surg Clin North Am 88(3):451–v. https://doi.org/10.1016/j.suc.2008.03.006

    Article  PubMed  Google Scholar 

  2. Choi JH, Ro JY (2021) The 2020 WHO Classification of Tumors of Soft Tissue: Selected Changes and New Entities. Adv Anat Pathol 28(1):44–58. https://doi.org/10.1097/PAP.0000000000000284

    Article  PubMed  Google Scholar 

  3. Boring CC, Squires TS, Tong T (1993) Cancer statistics, 1993. CA Cancer J Clin 43(1):7–26. https://doi.org/10.3322/canjclin.43.1.7

    Article  CAS  PubMed  Google Scholar 

  4. Saltus CW, Calingaert B, Candrilli S et al (2018) Epidemiology of Adult Soft-Tissue Sarcomas in Germany. Sarcoma 2018:5671926. https://doi.org/10.1155/2018/5671926

    Article  PubMed  PubMed Central  Google Scholar 

  5. American Cancer Society. Cancer Facts & Figures (2021) American Cancer Society: Atlanta, GA, USA, 2021; Available online: https://www.cancer.org/cancer/soft-tissue-sarcoma/about/key-statistics.html#references. Accessed on 21 October 2022

  6. Penel N, Grosjean J, Robin YM, Vanseymortier L, Clisant S, Adenis A (2008) Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases. Sarcoma 2008:459386. https://doi.org/10.1155/2008/459386

    Article  PubMed  PubMed Central  Google Scholar 

  7. Dugandzija T, Mikov MM, Solajic N, Nikolin B, Trifunovic J, Ilic M (2014) Increasing frequency of soft tissue sarcomas in Vojvodina - comparison with the literature. Asian Pac J Cancer Prev 15(2):1011–1014. https://doi.org/10.7314/apjcp.2014.15.2.1011

    Article  PubMed  Google Scholar 

  8. Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin L, Parkin DM, Whelan S (Eds.) (2013) International Classification of Diseases for Oncology (ICD-O), 3rd ed.; World Health Organization: Geneva, Switzerland, 2013; Available online: https://apps.who.int/iris/bitstream/handle/10665/96612/9789241548496_eng.pdf. Accessed on 20 October 2022

  9. Gupta A, Rao HK, Gupta S (2009) The incidence of soft tissue sarcoma in Dakshina Kannada: study in a District Government Hospital. Indian J Surg 71(1):10–14. https://doi.org/10.1007/s12262-009-0003-x

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ray-Coquard I, Montesco MC, Coindre JM et al (2012) Sarcoma: concordance between initial diagnosis and centralized expert review in a population-based study within three European regions. Ann Oncol 23(9):2442–2449. https://doi.org/10.1093/annonc/mdr610

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Alorjani MS, Matalka II, Alfaqih MA et al (2022) Soft Tissue Sarcomas: A 16-Year Experience of a Tertiary Referral Hospital in North Jordan. Medicina (Kaunas) 58(2):198. https://doi.org/10.3390/medicina58020198

    Article  PubMed  Google Scholar 

  12. Bhurgri Y, Bhurgri H, Pervez S et al (2008) Epidemiology of soft tissue sarcomas in Karachi South, Pakistan (1995–7). Asian Pac J Cancer Prev 9(4):709–714

    PubMed  Google Scholar 

  13. Mastrangelo G, Coindre JM, Ducimetière F et al (2012) Incidence of soft tissue sarcoma and beyond: a population-based prospective study in 3 European regions. Cancer 118(21):5339–5348. https://doi.org/10.1002/cncr.27555

    Article  PubMed  Google Scholar 

  14. Ferrari A, Sultan I, Huang TT, Rodriguez-Galindo C, Shehadeh A, Meazza C, Ness KK, Casanova M, Spunt SL (2011) Soft tissue sarcoma across the age spectrum: A population-based study from the Surveillance Epidemiology and End Results database. Pediatr Blood Cancer 57:943–949

    Article  PubMed  PubMed Central  Google Scholar 

  15. Toro JR, Travis LB, Wu HJ, Zhu K, Fletcher CD, Devesa SS (2006) Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: An analysis of 26,758 cases. Int J Cancer 119(12):2922–2930. https://doi.org/10.1002/ijc.22239

    Article  CAS  PubMed  Google Scholar 

  16. Ogura K, Higashi T, Kawai A (2017) Statistics of soft-tissue sarcoma in Japan: Report from the Bone and Soft Tissue Tumor Registry in Japan. J Orthop Sci 22(4):755–764. https://doi.org/10.1016/j.jos.2017.03.017

    Article  PubMed  Google Scholar 

  17. Fabiano S, Contiero P, Barigelletti G et al (2020) Epidemiology of Soft Tissue Sarcoma and Bone Sarcoma in Italy: Analysis of Data from 15 Population-Based Cancer Registries. Sarcoma 2020:6142613

    Article  Google Scholar 

  18. Ebrahimpour Adel, Chehrassan Mohammadreza, Sadighi Mehrdad, Karimi Amin, Looha Mehdi Azizmohammad, Kafiabadi MeisamJafari et al (2022) Soft Tissue Sarcoma of Extremities: Descriptive Epidemiological Analysis According to National Population-based Study. Arch Bone Jt Surg 10(1):67–77. https://doi.org/10.22038/abjs.2021.53750.2676

    Article  PubMed  PubMed Central  Google Scholar 

  19. Lawrence W Jr, Donegan WL, Natarajan N, Mettlin C, Beart R, Winchester D (1987) Adult soft tissue sarcomas. A pattern of care survey of the American College of Surgeons. Ann Surg 205(4):349–359. https://doi.org/10.1097/00000658-198704000-00003

    Article  PubMed  PubMed Central  Google Scholar 

  20. La TH, Wolden SL, Rodeberg DA et al (2011) Regional nodal involvement and patterns of spread along in-transit pathways in children with rhabdomyosarcoma of the extremity: a report from the Children’s Oncology Group. Int J Radiat Oncol Biol Phys 80(4):1151–1157. https://doi.org/10.1016/j.ijrobp.2010.03.050

    Article  PubMed  Google Scholar 

  21. Enneking WF, Spanier SS, Malawer MM (1981) The effect of the Anatomic setting on the results of surgical procedures for soft parts sarcoma of the thigh. Cancer 47(5):1005–1022. https://doi.org/10.1002/1097-0142(19810301)47:5%3c1005::aid-cncr2820470532%3e3.0.co;2-9

    Article  CAS  PubMed  Google Scholar 

  22. Pisters PW, Pollock RE, Lewis VO et al (2007) Long-term results of prospective trial of surgery alone with selective use of radiation for patients with T1 extremity and trunk soft tissue sarcomas. Ann Surg 246(4):675–81. https://doi.org/10.1097/sla.0b013e318155a9ae

    Article  PubMed  Google Scholar 

  23. Rydholm A, Gustafson P, Rööser B, Willén H, Berg NO (1991) Subcutaneous sarcoma. A population-based study of 129 patients. J Bone Joint Surg Br 73(4):662–667. https://doi.org/10.1302/0301-620X.73B4.2071656

    Article  CAS  PubMed  Google Scholar 

  24. Rosenberg SA, Tepper J, Glatstein E et al (1982) The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196(3):305–315. https://doi.org/10.1097/00000658-198209000-00009

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Cheng EY, Dusenbery KE, Winters MR, Thompson RC (1996) Soft tissue sarcomas: preoperative versus postoperative radiotherapy. J Surg Oncol 61(2):90–99. https://doi.org/10.1002/(SICI)1096-9098(199602)61:2%3c90::AID-JSO2%3e3.0.CO;2-M

    Article  CAS  PubMed  Google Scholar 

  26. Baldini EH, Lapidus MR, Wang Q et al (2013) Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: importance of tumor proximity to skin surface. Ann Surg Oncol 20(5):1494–1499. https://doi.org/10.1245/s10434-012-2797-1

    Article  PubMed  Google Scholar 

  27. Sarcoma Meta-analysis Collaboration (1997) Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Lancet 350:1647–1654

  28. Yang JC, Chang AE, Baker AR et al (1998) Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16(1):197–203. https://doi.org/10.1200/JCO.1998.16.1.197

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We acknowledge the help of all the faculty members and the staff of Radiotherapy department of our institute.We would also like to thank all the patients and their relatives whose data was used in this study

Author information

Authors and Affiliations

  1. Department of Radiotherapy, Nilratan Sircar Medical College and Hospital Ajc Bose Road, Kolkata, 700014, West Bengal, India

    Linkon Biswas, Anindita Ray, Sumitava De, Koustav Biswas & Srikrishna Mandal

Authors
  1. Linkon Biswas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anindita Ray
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sumitava De
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Koustav Biswas
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Srikrishna Mandal
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Linkon Biswas: Conceptualization, Writing- Original draft preparation.

Anindita Ray: Data curation, Investigation.

Sumitava De: Methodology, Visualization, Validation.

Koustav Biswas: Formal analysis, Writing- Reviewing and Editing.

Srikrishna Mandal: Supervision, Writing- Reviewing and Editing.

Corresponding author

Correspondence to Koustav Biswas.

Ethics declarations

Ethics Approval

This is an observational study. The Institutional Ethics Committee of Nilratan Sircar Medical College and Hospital has given ethical approval required for this study (No-NRSMC/IEC/109/2022, Dated 11/10/2022).

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Biswas, L., Ray, A., De, S. et al. Clinico-Demographic Profile Of Soft Tissue Sarcoma- 5 Year Experience From A Tertiary Care Centre Of Eastern India. Indian J Surg Oncol 15 (Suppl 1), 62–68 (2024). https://doi.org/10.1007/s13193-023-01734-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-023-01734-8

Keywords

Search

Navigation