Skip to main content

Advertisement

Log in

Somatic Malignant Transformation in Ovarian Mature Cystic Teratoma — Case Series from a Tertiary Cancer Centre in India

  • Case Series
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Rathore R, Sharma S, Agarwal S (2018) Malignant transformation in mature cystic teratoma of the ovary: a retrospective study of eight cases and review of literature. Prz Menopauzalny 17(2):63–68. https://doi.org/10.5114/pm.2018.77304

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kim MJ, Kim NY, Lee D-Y, Yoon B-K, Choi D (2011) Clinical characteristics of ovarian teratoma: age-focused retrospective analysis of 580 cases. Am J Obstet Gynecol 205(1):32.e1–4. https://doi.org/10.1016/j.ajog.2011.02.044

    Article  PubMed  Google Scholar 

  3. Tehranian A, Ghahghaei-Nezamabadi A, Seifollahi A, Kasraei S, Dehghani-Nejad H, Maleki-Hajiagha A (2021) Ovarian mature cystic teratoma with malignant transformation: two case reports. J Med Case Rep 15(1):23. https://doi.org/10.1186/s13256-020-02594-4

    Article  Google Scholar 

  4. Hackethal A, Brueggmann D, Bohlmann MK, Franke FE, Tinneberg H-R, Münstedt K (2008) Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data. Lancet Oncol 9(12):1173–1180. https://doi.org/10.1016/S1470-2045(08)70306-1

    Article  PubMed  Google Scholar 

  5. Chiang AJ, Chen MY, Weng CS, Lin H, Lu CH, Wang PH et al (2017) Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study. J Gynecol Oncol 28(5):e69. https://doi.org/10.3802/jgo.2017.28.e69

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Das P, Sable M, Nath D, Chumbar S, Das C, Priyadarshini P et al (2014) Pelvic mature cystic teratoma with neuroendocrine carcinoma: report of a rare association and review of literature. Indian J Pathol Microbiol 57(1):113–115

    Article  PubMed  Google Scholar 

  7. Black JD, Roque DM, Pasternak MC, Buza N, Rutherford TJ, Schwartz PE et al (2015) A series of malignant ovarian cancers arising from within a mature cystic teratoma: a single institution experience. Int J Gynecol Cancer 25(5):792–797

    Article  PubMed  Google Scholar 

  8. Wen K-C, Hu W-M, Twu N-F, Chen P, Wang P-H (2006) Poor prognosis of intraoperative rupture of mature cystic teratoma with malignant transformation. Taiwan J Obstet Gynecol 45(3):253–256. https://doi.org/10.1016/S1028-4559(09)60236-9

    Article  PubMed  Google Scholar 

  9. Park J-Y, Kim D-Y, Kim J-H, Kim Y-M, Kim Y-T, Nam J-H (2008) Malignant transformation of mature cystic teratoma of the ovary: experience at a single institution. Eur J Obstet Gynecol Reprod Biol 141(2):173–178. https://doi.org/10.1016/j.ejogrb.2008.07.032

    Article  PubMed  Google Scholar 

  10. Sakuma M, Otsuki T, Yoshinaga K, Utsunomiya H, Nagase S, Takano T et al (2010) Malignant transformation arising from mature cystic teratoma of the ovary: a retrospective study of 20 cases. Int J Gynecol Cancer 20(5):766–771. https://doi.org/10.1111/igc.0b013e3181daaf1d

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lakshmi Haridas Kamala.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Key Concluding Points

• MT arising from OMCT is a rare, aggressive malignancy with dismal outcome.

• Early detection and early FIGO stage carries better prognosis.

• Less diagnosed preoperatively than pathological. High index of suspicion and thorough histological examination is crucial in diagnosis.

• Optimal cytoreduction is the surgical dictum.

• Combined platinum/taxane chemotherapy seems to improve survival in advanced-stage disease.

Previous Publications/Presentations

Nil.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kamala, L.H., Abraham, S., Radhakrishnan, N. et al. Somatic Malignant Transformation in Ovarian Mature Cystic Teratoma — Case Series from a Tertiary Cancer Centre in India. Indian J Surg Oncol 14, 150–154 (2023). https://doi.org/10.1007/s13193-022-01630-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-022-01630-7

Navigation