Skip to main content
SpringerLink
Log in

Isolated Limb Perfusion of Upper Limb: How I Do It

  • Point of Technique
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Ferrone ML, Raut CP (2012) Modern surgical therapy: limb salvage and the role of amputation for extremity soft-tissue sarcomas. Surg Oncol Clin N Am 21(2):201–213

    Article  Google Scholar 

  2. von Mehren M, Kane JM, Bui MM, Choy E, Connelly M, Dry S et al (2020) NCCN guidelines insights: soft tissue sarcoma, Version 1.2021. J Natl Compr Canc Netw 18(12):1604–12

    Article  Google Scholar 

  3. Erstad DJ, Raut CP (2018) Amputation for sarcoma: revisiting a 19th century treatment in the 21st century. Ann Surg Oncol 25(2):351–353

    Article  Google Scholar 

  4. Rosenberg SA, Tepper J, Glatstein E, Costa J, Baker A, Brennan M et al (1982) The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196(3):305–315

    Article  CAS  Google Scholar 

  5. Krikelis D, Judson I (2010) Role of chemotherapy in the management of soft tissue sarcomas. Expert Rev Anticancer Ther 10(2):249–260

    Article  CAS  Google Scholar 

  6. Istl AC, Ruck JM, Morris CD, Levin AS, Meyer CF, Johnston FM (2019) Call for improved design and reporting in soft tissue sarcoma studies: a systematic review and meta-analysis of chemotherapy and survival outcomes in resectable STS. J Surg Oncol 119(7):824–835

    Article  Google Scholar 

  7. Jakob J, Hohenberger P (2016) Role of isolated limb perfusion with recombinant human tumor necrosis factor alpha and melphalan in locally advanced extremity soft tissue sarcoma. Cancer 122(17):2624–2632

    Article  CAS  Google Scholar 

  8. Cherix S, Speiser M, Matter M, Raffoul W, Lienard D, Theumann N et al (2008) Isolated limb perfusion with tumor necrosis factor and melphalan for non-resectable soft tissue sarcomas: long-term results on efficacy and limb salvage in a selected group of patients. J Surg Oncol 98(3):148–155

    Article  Google Scholar 

  9. Verhoef C, de Wilt JH, Grunhagen DJ, van Geel AN, ten Hagen TL, Eggermont AM (2007) Isolated limb perfusion with melphalan and TNF-alpha in the treatment of extremity sarcoma. Curr Treat Options Oncol 8(6):417–427

    Article  Google Scholar 

  10. Deneve JL, Zager JS (2012) Isolated regional therapy for advanced extremity soft tissue sarcomas. Surg Oncol Clin N Am 21(2):287–299

    Article  Google Scholar 

  11. Lejeune FJ, Pujol N, Lienard D, Mosimann F, Raffoul W, Genton A et al (2000) Limb salvage by neoadjuvant isolated perfusion with TNFalpha and melphalan for non-resectable soft tissue sarcoma of the extremities. Eur J Surg Oncol 26(7):669–678

    Article  CAS  Google Scholar 

  12. Podleska LE, Poeppel T, Herbrik M, Dahlkamp L, Grabellus F, Taeger G (2014) Drug dosage in isolated limb perfusion: evaluation of a limb volume model for extremity volume calculation. World J Surg Oncol 12:81

    Article  Google Scholar 

  13. Spacek M, Mitas P, Vocka M, Lacina L, Hodkova G, Spunda R, et al. (n.d) Isolated Perfusion of the Upper Extremity with TNF-alpha - Double Venous Cannulation. Klin Onkol.30(3):213–9.

  14. Minor DR, Allen RE, Alberts D, Peng YM, Tardelli G, Hutchinson J (1985) A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma. Cancer 55(11):2638–2644

    Article  CAS  Google Scholar 

  15. Wieberdink J, Benckhuysen C, Braat RP, van Slooten EA, Olthuis GA (1982) Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions. Eur J Cancer Clin Oncol 18(10):905–910

    Article  CAS  Google Scholar 

  16. Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R et al (2009) New response evaluation criteria in solid tumours revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228–47

    Article  CAS  Google Scholar 

  17. Podleska LE, Kaya N, Farzaliyev F, Pottgen C, Bauer S, Taeger G (2017) Lower limb function and quality of life after ILP for soft-tissue sarcoma. World J Surg Oncol 15(1):84

    Article  Google Scholar 

  18. Puhaindran ME, Steensma MR, Athanasian EA (2010) Partial hand preservation for large soft tissue sarcomas of the hand. J Hand Surg Am 35(2):291–295

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Oncology, Cancer Institute (WIA), 38, Sardar Patel Road, Adyar, Chennai, 600036, India

    Chandra Kumar Krishnan, Anand Karnawat & Anand Raja

  2. Department of Anaesthesia, Cancer Institute (WIA), 38, Sardar Patel Road, Adyar, Chennai, 600036, India

    Punitha Arivazhagan

Authors
  1. Chandra Kumar Krishnan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Punitha Arivazhagan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anand Karnawat
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anand Raja
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anand Raja.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Krishnan, C.K., Arivazhagan, P., Karnawat, A. et al. Isolated Limb Perfusion of Upper Limb: How I Do It. Indian J Surg Oncol 13, 776–779 (2022). https://doi.org/10.1007/s13193-022-01561-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-022-01561-3

Search

Navigation