Abstract
Papillary thyroid carcinoma (PTC) is the most common malignant tumour of the thyroid and it is often found in association with Hashimoto’s thyroiditis (HT). This concomitance is still under debate. The aim of this study is to investigate the influence of Hashimoto’s thyroiditis in patients with papillary thyroid carcinoma. Two thousand two hundred eighteen patients underwent thyroidectomy in our department between January 2015 and January 2020. Of these, 435 patients had surgery for papillary thyroid carcinoma and form the basis of our studies. The association between PTC and HT was found in 180 patients (41.4%), mostly represented in the female group (78.9%), with a lower median age than patients with PTC without HT. In comparison to patients with PTC alone, the PTC-HT group had less invasive and smaller tumours, as well as less lymph node involvement. Moreover, tumours of patients with PTC-HT were diagnosed earlier. Our data showed that Hashimoto’s thyroiditis may be considered a protective factor when PTC develops. Furthermore, we concluded that patients with PTC and HT had a better prognosis and a lower risk of recurrence than those that did not have HT.
Similar content being viewed by others
References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
Liu S, Semenciw R, Ugnat AM, Mao Y (2001) Increasing thyroid cancer incidence in Canada, 1970–1996: time trends and age-period-cohort effects. Br J Cancer 85(9):1335–1339
Gimm O (2001) Thyroid cancer. Cancer Lett 163(2):143–156
Repplinger D, Bargren A, Zhang YW, Adler JT, Haymart M, Chen H (2008) Is Hashimoto’s thyroiditis a risk factor for papillary thyroid cancer? J Surg Res 150(1):49–52
Mincer, D. L., & Jialal, I. (2019). Hashimoto thyroiditis. In StatPearls [Internet]. StatPearls Publishing.
Caturegli P, De Remigis A, Rose NR (2014) Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev 13(4–5):391–397
Dailey ME, Lindsay S, Skahen R (1955) Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg 70(2):291–297
Resende de Paiva C, Grønhøj C, Feldt-Rasmussen U, von Buchwald C (2017) Association between Hashimoto’s thyroiditis and thyroid cancer in 64,628 patients. Front Oncol 7:53
Consorti F, Loponte M, Milazzo F, Potasso L, Antonaci A (2010) Risk of malignancy from thyroid nodular disease as an element of clinical management of patients with Hashimoto’s thyroiditis. Eur Surg Res 45(3–4):333–337
Fiore E, Latrofa F, Vitti P (2015) Iodine, thyroid autoimmunity and cancer. Eur Thyroid J 4(1):26–35
Farrell E, Heffron C, Murphy M, O’Leary G, Sheahan P (2017) Impact of lymphocytic thyroiditis on incidence of pathological incidental thyroid carcinoma. Head Neck 39(1):122–127
Jackson D, Handelsman RS, Farrá JC, Lew JI (2020) Increased incidental thyroid cancer in patients with subclinical chronic lymphocytic thyroiditis. J Surg Res 245:115–118
Williams ED, Abrosimov A, Bogdanova T, Demidchik EP, Ito M, LiVolsi V, Tsyb AF (2004) Thyroid carcinoma after Chernobyl latent period, morphology and aggressiveness. Br J Cancer 90(11):2219–2224
Negri E, Dal Maso L, Ron E, La Vecchia C, Mark SD, Preston-Martin S, Wingren G (1999) A pooled analysis of case-control studies of thyroid cancer¶ II. Menstrual and reproductive factors. Cancer Causes Control 10(2):143–155
Franceschi S, Preston-Martin S, Dal Maso L, Negri E, La Vecchia C, Mack WJ, Jin F (1999) A pooled analysis of case–control studies of thyroid cancer. IV. Benign thyroid diseases. Cancer Causes Control 10(6):583–595
Musholt TJ, Musholt PB, Petrich T, Oetting G, Knapp WH, Klempnauer J (2000) Familial papillary thyroid carcinoma: genetics, criteria for diagnosis, clinical features, and surgical treatment. World J Surg 24(11):1409–1417
Soveid M, Monabbati A, Sooratchi L, Dahti S (2007) The effect of iodine prophylaxis on the frequency of thyroiditis and thyroid tumors in Southwest, Iran. Saudi Med J 28(7):1034
Lee JH, Kim Y, Choi JW, Kim YS (2013) The association between papillary thyroid carcinoma and histologically proven Hashimoto’s thyroiditis: a meta-analysis. Eur J Endocrinol 168(3):343–349
McLeod DS, Watters KF, Carpenter AD, Ladenson PW, Cooper DS, Ding EL (2012) Thyrotropin and thyroid cancer diagnosis: a systematic review and dose-response meta-analysis. J Clin Endocrinol Metab 97(8):2682–2692
Paparodis RD, Bantouna D, Karvounis E, Imam S, Jaume JC (2020) Higher TSH is not associated with thyroid cancer risk in the presence of thyroid autoimmunity. J Clin Endocrinol Metab 105(7):dgaa237
Tamimi DM (2002) The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol 10(2):141–146
Wirtschafter A, Schmidt R, Rosen D, Kundu N, Santoro M, Fusco A, Rothstein JL (1997) Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto’s thyroiditis. Laryngoscope 107(1):95–100
Unger P, Ewart M, Wang BY, Gan LI, Kohtz DS, Burstein DE (2003) Expression of p63 in papillary thyroid carcinoma and in Hashimoto’s thyroiditis: a pathobiologic link? Hum Pathol 34(8):764–769
Kim SS, Lee BJ, Lee JC, Kim SJ, Jeon YK, Kim MR, Kim IJ (2011) Coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma: the influence of lymph node metastasis. Head Neck 33(9):1272–1277
Zhang Y, Dai J, Wu T, Yang N, Yin Z (2014) The study of the coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol 140(6):1021–1026
Ahn D, Heo SJ, Park JH, Kim JH, Sohn JH, Park JY, Park J (2011) Clinical relationship between Hashimoto’s thyroiditis and papillary thyroid cancer. Acta Oncol 50(8):1228–1234
Jeong JS, Kim HK, Lee CR, Park S, Park JH, Kang SW, Park CS (2012) Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome. J Korean Med Sci 27(8):883–889
Dvorkin S, Robenshtok E, Hirsch D, Strenov Y, Shimon I, Benbassat CA (2013) Differentiated thyroid cancer is associated with less aggressive disease and better outcome in patients with coexisting Hashimotos thyroiditis. J Clin Endocrinol Metab 98(6):2409–2414
Marotta V, Sciammarella C, Chiofalo MG, Gambardella C, Bellevicine C, Grasso M, Troncone G (2017) Hashimoto’s thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer. Endocr Relat Cancer 24(9):485–493
Toniato A, Boschin I, Casara D, Mazzarotto R, Rubello D, Pelizzo M (2008) Papillary thyroid carcinoma: factors influencing recurrence and survival. Ann Surg Oncol 15(5):1518–1522. https://doi.org/10.1245/s10434-008-9859-4
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing Interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Battistella, E., Pomba, L., Costantini, A. et al. Hashimoto’s Thyroiditis and Papillary Cancer Thyroid Coexistence Exerts a Protective Effect: a Single Centre Experience. Indian J Surg Oncol 13, 164–168 (2022). https://doi.org/10.1007/s13193-022-01515-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-022-01515-9