Skip to main content
SpringerLink
Log in

Hypothyroidism Presenting as Ovarian Cysts—a Case Series

Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Cite this article

Abstract

Ovarian cysts can be caused by endocrine disorders. Hypothyroidism causing ovarian cysts is an uncommon entity, but rarely does it cause an ovarian cyst which can mimic malignancy. We report three cases of ovarian masses which were referred to our institute suspecting malignancy. These patients on further evaluation were found to have severe hypothyroidism and started on thyroxine supplementation. There was dramatic symptomatic relief as well as resolution of the ovarian masses on subsequent imaging. Hypothyroidism should be considered in the differential diagnosis of bilateral multicystic adnexal masses to avoid inadvertent surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Van Wyk JJ, Grumbach MM (1960) Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback. J Pediatr 57:20

    Article  Google Scholar 

  2. Yamashita Y, Kawamura T, Fujikawa R, Mochizuki H, Okubo M, Arita K (2001) Regression of both pituitary and ovarian cysts after administration of thyroid hormone in a case of primary hypothyroidism. Intern Med 40:751–755. https://doi.org/10.2169/internalmedicine.40.751

    Article  CAS  PubMed  Google Scholar 

  3. Hansen KA, Tho SP, Hanly M, Moretuzzo RW, McDonough PG (1997) Massive ovarian enlargement in primary hypothyroidism. Fertil Steril 67:169–171. https://doi.org/10.1016/S0015-0282(97)81876-6

    Article  CAS  PubMed  Google Scholar 

  4. Krassas GE, Poppe K, Glinoer D (2010) Thyroid function and human reproductive health. Endocr Rev 31(5):702–755

    Article  CAS  Google Scholar 

  5. Shivaprasad KS, Dutta D, Jain R, Kumar M, Maisnam I, Biswas D et al (2013) Huge bilateral ovarian cysts in adulthood as the presenting feature of Van Wyk Grumbach syndrome due to chronic uncontrolled juvenile hypothyroidism. Indian J Endocr Metab 17:S164–S166

    Article  CAS  Google Scholar 

  6. Ramesan C, Unnikrishnan E, Firoz Babu K (2016) Incidence of ovarian cyst in hypothyroidism: an institutional study. J Evid Based Med Healthc 3(78):4236–4241. https://doi.org/10.18410/jebmh/2016/902

    Article  Google Scholar 

  7. Aghajanova L, Lindeberg M, Carlsson IB (2009) Receptors for thyroid stimulating hormone and thyroid hormones in human ovarian tissue. Reprod BioMed Online 18:337–347. https://doi.org/10.1016/S1472-6483(10)60091-0

    Article  CAS  PubMed  Google Scholar 

  8. Shu et al (2011) Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness. Reprod Biol Endocrinol 9:119

    Article  Google Scholar 

  9. Hashimoto T, Matsubara F (1989) Changes in the tumor marker concentration in female patients with hyper-, eu-, and hypothyroidism. Endocrinol Jpn 36:873–879

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gynecological Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India

    Anila Tresa, Prabhakaran Rema, S. Suchetha, Dhanya Dinesh & Aswathy G. Nath

  2. Division of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India

    J. Sivaranjith

Authors
  1. Anila Tresa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prabhakaran Rema
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Suchetha
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dhanya Dinesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Sivaranjith
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Aswathy G. Nath
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anila Tresa.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tresa, A., Rema, P., Suchetha, S. et al. Hypothyroidism Presenting as Ovarian Cysts—a Case Series. Indian J Surg Oncol 12 (Suppl 2), 343–347 (2021). https://doi.org/10.1007/s13193-020-01263-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-020-01263-8

Keywords

search

Navigation