Abstract
A vast majority of oral cancer patients in developing countries present in an advanced stage with borderline resectable/inoperable stage to busy resource-constrained tertiary cancer centers. Conventional chemotherapy protocols are associated with issues like toxicity, tolerance, cost, and compliance. The present study was conducted to assess the feasibility of low-cost home-based chemotherapy options. Single-arm feasibility study was done in borderline resectable/inoperable oral cancer patients. Home-based oral neoadjuvant chemotherapy consisting of oral methotrexate 15 mg/m2 once a week and oral celecoxib 200 mg twice daily for 8 weeks was used. RECIST Criteria 1.1 was used to assess response to therapy. The study included 60 patients. The mean age was 51.98 years with male predominance (80%). Fifty-five patients adhered to the treatment; the compliance rate is 91.60%. Affordability (Rs 700 per month) and tolerance to therapy was 100%, and no grade III or IV toxicity was seen. Overall, 18 patients had stable disease (32.73%), partial response was seen in 15 patients (27.27%), and the disease progressed in 22 patients (40%). At the end of 8 weeks, 26 (43.3%) patients were deemed resectable. Neoadjuvant low cost, home-based metronomic chemotherapy using oral methotrexate and celecoxib seems to be a viable option in managing advanced oral cancer in resource-constrained setups.
Similar content being viewed by others
References
India State-Level Disease Burden Initiative Cancer Collaborators (2018) The burden of cancers and their variations across the states of India: the Global Burden of Disease Study 1990–2016 [published correction appears in Lancet Oncol. 2018 Oct 3]. Lancet Oncol 19(10):1289–1306. https://doi.org/10.1016/S1470-2045(18)30447-9
Pai PS, Vaidya AD, Prabhash K, Banavali SD (2013) Oral metronomic scheduling of anticancer therapy-based treatment compared to existing standard of care in locally advanced oral squamous cell cancers: a matched-pair analysis. Indian J Cancer 50(2):135–141. https://doi.org/10.4103/0019-509X.117024
Scharovsky OG, Mainetti LE, Rozados VR (2009) Metronomic chemotherapy: changing the paradigm that more is better. Curr Oncol 16(2):7–15. https://doi.org/10.3747/co.v16i2.420
Kerbel RS, Kamen BA (2004) The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 4(6):423–436. https://doi.org/10.1038/nrc1369
Coelho KR (2012) Challenges of the oral cancer burden in India. J Cancer Epidemiol 2012:701932–701917. https://doi.org/10.1155/2012/701932
Goyal G (2016) Knowledge, attitude and practice of chewing gutka, areca nut, snuff and tobacco smoking among the young population in the Northern India Population. Asian Pac J Cancer Prev 17(11):4813–481. Published 2016 Nov 1. https://doi.org/10.22034/APJCP.2016.17.11.4813
Shah S, Dave B, Shah R, Mehta TR, Dave R (2018) Socioeconomic and cultural impact of tobacco in India. J Family Med Prim Care 7(6):1173–1176. https://doi.org/10.4103/jfmpc.jfmpc_36_18
Hashitani S, Urade M, Nishimura N, Maeda T, Takaoka K, Noguchi K, Sakurai K (2003) Apoptosis induction and enhancement of cytotoxicity of anticancer drugs by celecoxib, a selective cyclooxygenase-2 inhibitor, in human head and neck carcinoma cell lines. Int J Oncol 23(3):665–672
Kerr DJ, Midgley R (2010) Can we treat cancer for a dollar a day? Guidelines for low-income countries. N Engl J Med 363(9):801–803. https://doi.org/10.1056/NEJMp1002812
Smith TJ, Hillner BE (2011) Bending the cost curve in cancer care. N Engl J Med 364(21):2060–2065. https://doi.org/10.1056/NEJMsb1013826
Vishak S, Rangarajan B, Kekatpure VD (2015) Neoadjuvant chemotherapy in oral cancers: selecting the right patients. Indian J Med Paediatr Oncol 36(3):148–153. https://doi.org/10.4103/0971-5851.166716
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sultania, M., Deo, S.V.S., Shukla, N.K. et al. Low Cost, Low Dose, Oral, Neoadjuvant Chemotherapy Protocol in Locally Advanced Borderline Oral Cancers—Feasibility Study. Indian J Surg Oncol 12, 67–72 (2021). https://doi.org/10.1007/s13193-020-01247-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-020-01247-8