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Bilateral Primary Ovarian Clear Cell Carcinoma in an Iranian Woman: a Case Report

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Abbreviations

OCCC :

ovarian clear cell carcinoma

EOCs :

epithelial ovarian carcinomas

ARID1A :

AT-rich interaction domain 1A

PIK3CA :

phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic sub-unit alpha

MET :

mesenchymal-epithelial transition

MRI :

magnetic resonance imaging

CT:

computerized tomography scan

CBC :

complete blood count

CA 125:

cancer antigen 125

AFP :

alpha fetoprotein

CEA:

carcinoembryonic antigen

IHC :

immunohistochemistry

CK7:

cytokeratin 7

CD10:

cluster of differentiation 10

CD20:

cluster of differentiation 20

FIGO:

International Federation of Gynecology and Obstetrics

References

  1. Ranaee M, Yazdani S, Modarres SR, Rajabi-Moghaddam M (2016) Two cases of clear cell ovarian cancer in young patients. Caspian J Intern Med 7(3):228–231

    PubMed  PubMed Central  Google Scholar 

  2. Katke RD, Bhansali MS, Gohil D (2015) Huge clear cell carcinomas of ovary: a case series. J Case Rep 4(2):515–519

    Google Scholar 

  3. Ji JX, Wang YK, Cochrane DR, Huntsman DG (2018) Clear cell carcinomas of the ovary and kidney: clarity through genomics. J Pathol 244(5):550–564

    Article  CAS  Google Scholar 

  4. Tang H, Liu Y, Wang X, Guan L, Chen W, Jiang H, Lu Y (2018) Clear cell carcinoma of the ovary: clinicopathologic features and outcomes in a Chinese cohort. Medicine. 97(21):e10881

    Article  CAS  Google Scholar 

  5. Li M, Li H, Liu F, Bi R, Tu X, Chen L, Ye S, Cheng X (2017) Characterization of ovarian clear cell carcinoma using target drug-based molecular biomarkers: implications for personalized cancer therapy. J Ovarian Res 10(1):9

    Article  Google Scholar 

  6. Son JH, Yoon S, Kim S, Kong TW, Paek J, Chang SJ, Ryu HS (2019) Clinicopathologic characteristics of ovarian clear cell carcinoma in the background of endometrioma: a surveillance strategy for an early detection of malignant transformation in patients with asymptomatic endometrioma. Obstet Gynecol Sci 62(1):27–34

    Article  Google Scholar 

  7. Momenimovahed Z, Tiznobaik A, Taheri S, Salehiniya H (2019) Ovarian cancer in the world: epidemiology and risk factors. Int J Women's Health 11:287–299

    Article  Google Scholar 

  8. Gaitskell K, Green J, Pirie K, Barnes I, Hermon C, Reeves GK, Beral V, Million Women Study Collaborators (2018) Histological subtypes of ovarian cancer associated with parity and breastfeeding in the prospective million women study. Int J Cancer 142(2):281–289

    Article  CAS  Google Scholar 

  9. Win TT, Nik Mahmood NMZ, Ma SO, Ismail M (2016) Bilateral ovarian clear cell carcinoma arising in 17 year longstanding history of bilateral ovarian endometriosis. Iran J Pathol 11(5):478–482

    PubMed  Google Scholar 

  10. Brilhante AV, Augusto KL, Portela MC, Sucupira LC, Oliveira LA, Pouchaim AJ, Nóbrega LR, Magalhães TF, Sobreira LR (2017) Endometriosis and ovarian cancer: an integrative review (endometriosis and ovarian cancer). Asian Pac J Cancer Prev 18(1):11–16

    PubMed  PubMed Central  Google Scholar 

  11. Latifi A, Luwor RB, Bilandzic M, Nazaretian S, Stenvers K, Pyman J, Zhu H, Thompson EW, Quinn MA, Findlay JK, Ahmed N (2012) Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors. PLoS One 7(10):e46858

    Article  CAS  Google Scholar 

  12. Suh DH, Chang SJ, Song T, Lee S, Kang WD, Lee SJ, Roh JW, Joo WD, Yoon JH, Jeong DH, Kim HS, Lee SJ, Ji YI, Kim HJ, Lee JW, Kim JW, Bae DS (2018) Practice guidelines for management of ovarian cancer in Korea: a Korean Society of Gynecologic Oncology Consensus Statement. Gynecol Oncol 29(4):e56

    Article  Google Scholar 

  13. Prat J (2014) Oncology FCoG. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet 124(1):1–5

    Article  Google Scholar 

  14. Ebell MH, Culp MB, Radke TJ (2016) A systematic review of symptoms for the diagnosis of ovarian cancer. Am J Prev Med 50(3):384–394

    Article  Google Scholar 

  15. Ma FH, Qiang JW, Zhang GF, Li HM, Cai SQ, Rao YM (2016) Magnetic resonance imaging for distinguishing ovarian clear cell carcinoma from high-grade serous carcinoma. J Ovarian Res 9(1):40

    Article  Google Scholar 

  16. Morioka S, Kawaguchi R, Yamada Y, Iwai K, Yoshimoto C, Kobayashi H (2019) Magnetic resonance imaging findings for discriminating clear cell carcinoma and endometrioid carcinoma of the ovary. J Ovarian Res 12(1):20

    Article  Google Scholar 

  17. Guo J, Yu J, Song X, Mi H (2017) Serum CA125, CA199 and CEA combined detection for epithelial ovarian cancer diagnosis: a meta-analysis. Open Med 12:131–137

    Article  CAS  Google Scholar 

  18. Chen F, Shen J, Wang J, Cai P, Huang Y (2018) Clinical analysis of four serum tumor markers in 458 patients with ovarian tumors: diagnostic value of the combined use of HE4, CA125, CA19-9, and CEA in ovarian tumors. Cancer Manag Res 10:1313–1318

    Article  CAS  Google Scholar 

  19. Moro F, Pasciuto T, Djokovic D, Di Legge A, Granato V, Moruzzi MC et al (2019) Role of CA125/CEA ratio and ultrasound parameters in identifying metastases to the ovaries in patients with multilocular and multilocular-solid ovarian masses. Ultrasound Obstet Gynecol 53(1):116–123

    Article  CAS  Google Scholar 

  20. Sorensen SS, Mosgaard BJ (2011) Combination of cancer antigen 125 and carcinoembryonic antigen can improve ovarian cancer diagnosis. Dan Med Bull 58(11):A4331

    PubMed  Google Scholar 

  21. Lin W, Cao D, Shen K (2018) Prognostic significance of preoperative serum CEA in primary mucinous ovarian carcinoma: a retrospective cohort study. Cancer Manag Res 10:6913–6920

    Article  CAS  Google Scholar 

  22. Babaier A, Ghatage P (2020) Mucinous cancer of the ovary: overview and current status. Diagnostics 10(1):52

    Article  CAS  Google Scholar 

  23. Kudoh K, Kikuchi Y, Kita T, Tode T, Takano M, Hirata J, Mano Y, Yamamoto K, Nagata I (1999) Preoperative determination of several serum tumor markers in patients with primary epithelial ovarian carcinoma. Gynecol Obstet Investig 47(1):52–57

    Article  CAS  Google Scholar 

  24. Rekhi B, Deodhar KK, Menon S, Maheshwari A, Bajpai J, Ghosh J, Shylasree ST, Gupta S (2018) Napsin a and WT 1 are useful immunohistochemical markers for differentiating clear cell carcinoma ovary from high-grade serous carcinoma. APMIS 126(1):45–55

    Article  CAS  Google Scholar 

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Acknowledgments

We announce our special thanks to the Clinical Research Center of Kosar Hospital and Mrs. Simindokht Molaverdikhani for assisting us in this project.

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Authors and Affiliations

  1. Faculty of Medical School, Qazvin University of Medical Sciences, Bahonar St, Qazvin, Iran

    Fatemeh Samiee-Rad

  2. General Physician, Qazvin University of Medical Sciences, Bahonar St, Qazvin, Iran

    Mahdi Ghaebi & Arezoo Bajelan

Authors
  1. Fatemeh Samiee-Rad
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  2. Mahdi Ghaebi
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  3. Arezoo Bajelan
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Contributions

First author (Fatemeh Samiee-Rad) contributed to the study conception and design. Material preparation, data collection, and case presentation were performed by Fatemeh Samiee-Rad, Mahdi Ghaebi, and Arezoo Bajelan. The first draft of the manuscript was written by Fatemeh Samiee-Rad and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Fatemeh Samiee-Rad.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All applicable international, national, and/or institutional guidelines followed.

Before patient was enrolled in this study, participant consent was obtained.

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Samiee-Rad, F., Ghaebi, M. & Bajelan, A. Bilateral Primary Ovarian Clear Cell Carcinoma in an Iranian Woman: a Case Report. Indian J Surg Oncol 12 (Suppl 1), 181–185 (2021). https://doi.org/10.1007/s13193-020-01234-z

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  • DOI: https://doi.org/10.1007/s13193-020-01234-z

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