Abstract
The cumulative survival for all stages in oral squamous cell cancers (OSCC) in the world remains poor despite the advances in management; hence, we conducted this study to evaluate the survival outcomes. This is a retrospective review and analysis of treatment, follow-up and survival records of 249 OSCC patients treated in our department from April 2010 to April 2014. Telephonic interviews were conducted for survival details for some patients who had not reported. Survival analysis was done using the Kaplan-Meier analysis, comparisons were done using log-rank test and multivariate analysis was conducted using the Cox proportional hazard model to find different variables (site, age, sex, stage and treatment) affecting overall survival (OS)/disease-free survival (DFS). Two-year and 5-year DFS for OSCC were observed to be 72.3% and 58.3% with mean survival of 63.17 months (95% CI: 58.342–68.002). Similarly, OS at 2 years and 5 years were 84.3% and 55.9% with mean survival of 65.143 months (95% CI: 60.143–69.601). Tumour site, patient age, stage of disease and treatment modality had a statistically significant hazardous effect on the overall and disease-free survival rates. The significant influence of age, site of tumour, stage of disease and modality of treatment required based on the clinic-pathologic risk factors on prognosis emphasizes the importance of early diagnosis through regular screening and early treatment which can be ensured with early referral, high clinical suspicion and awareness at the point of primary/secondary care.
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References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424. https://doi.org/10.3322/caac.21492
Coelho KR (2012) Challenges of the oral cancer burden in India. J Cancer Epidemiol 2012:1–17. https://doi.org/10.1155/2012/701932
Sreelatha SV, Shetty S, Karnaker VK, Chowdhury CR (2019) Patterns of Tobacco Consumption among Oral Squamous Cell Carcinoma Cases Attending a Tertiary Care Dental Hospital in Coastal Karnataka of India. World 10(5):351. https://doi.org/10.5005/jp-journals-10015-1663
Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, Soerjomataram I (2017) The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin 67:51–64. https://doi.org/10.3322/caac.21384
Trotta BM, Pease CS, Rasamny JJ, Raghavan P, Mukherjee S (2011) Oral cavity and oropharyngeal squamous cell cancer: key imaging findings for staging and treatment planning. RadioGraphics 31:339–354. https://doi.org/10.1148/rg.312105107
Flint P, Haughey BH, Lund VJ, et al (2010) Cummings otolaryngology head & neck surgery. In: Mosby, Inc. http://www.us.elsevierhealth.com/product.jsp?isbn=9780323052832&elsca1=doodys&elsca2=PDF&elsca3=Flint9780323052832&elsca4=frontmatter. Accessed 22 May 2019
National Comprehensive cancer network (NCCN) Guidelines. In: Natl. Compr. cancer Netw. https://www.nccn.org/professionals/physician_gls/default.aspx. Accessed 22 May 2019
Gourin CG, Johnson JT (2009) A contemporary review of indications for primary surgical care of patients with squamous cell carcinoma of the head and neck. Laryngoscope 119:2124–2134. https://doi.org/10.1002/lary.20619
Pruegsanusak K, Peeravut S, Leelamanit V, Sinkijcharoenchai W, Jongsatitpaiboon J, Phungrassami T, Chuchart K, Thongsuksai P (2012) Survival and prognostic factors of different sites of head and neck cancer: an analysis from Thailand. Asian Pac J Cancer Prev 13:885–890
Chandu A, Adams G, Smith ACH (2005) Factors affecting survival in patients with oral cancer: an Australian perspective. Int J Oral Maxillofac Surg 34:514–520. https://doi.org/10.1016/j.ijom.2004.10.006
Elango JK, Gangadharan P, Sumithra S, Kuriakose MA Trends of head and neck cancers in urban and rural India. Asian Pac J Cancer Prev 7:108–12
Kumar S, Heller RF, Pandey U, et al Delay in presentation of oral cancer: a multifactor analytical study. Natl Med J India 14:13–7
Conway DI, Petticrew M, Marlborough H, Berthiller J, Hashibe M, Macpherson LMD (2008) Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studies. Int J Cancer 122:2811–2819. https://doi.org/10.1002/ijc.23430
Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M, European Organization for Research and Treatment of Cancer Trial 22931 (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350:1945–1952. https://doi.org/10.1056/NEJMoa032641
Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, Machtay M, Ensley JF, Chao KS, Schultz CJ, Lee N, Fu KK, Radiation Therapy Oncology Group 9501/Intergroup (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350:1937–1944. https://doi.org/10.1056/NEJMoa032646
Chang T-S, Chang C-M, Ho H-C, Su YC, Chen LF, Chou P, Lee CC (2013) Impact of young age on the prognosis for oral cancer: a population-based study in Taiwan. PLoS One 8:e75855. https://doi.org/10.1371/journal.pone.0075855
Gilroy JS, Morris CG, Amdur RJ, Mendenhall WM (2005) Impact of young age on prognosis for head and neck cancer: a matched-pair analysis. Head Neck 27:269–273. https://doi.org/10.1002/hed.20145
Pytynia KB, Grant JR, Etzel CJ, Roberts D, Wei Q, Sturgis EM (2004) Matched analysis of survival in patients with squamous cell carcinoma of the head and neck diagnosed before and after 40 years of age. Arch Otolaryngol Neck Surg 130:869–873. https://doi.org/10.1001/archotol.130.7.869
Yang Y-H, Chen C-H, Chang JSF, Lin CC, Cheng TC, Shieh TY (2005) Incidence rates of oral cancer and oral pre-cancercous lesions in a 6-year follow-up study of a Taiwanese aboriginal community. J Oral Pathol Med 34:596–601. https://doi.org/10.1111/j.1600-0714.2005.00266.x
Mignogna MD, Fedele S, Lo Russo L (2004) The World Cancer Report and the burden of oral cancer. Eur J Cancer Prev 13:139–142
Iamaroon A, Pattanaporn K, Pongsiriwet S, Wanachantararak S, Prapayasatok S, Jittidecharaks S, Chitapanarux I, Lorvidhaya V (2004) Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. Int J Oral Maxillofac Surg 33:84–88. https://doi.org/10.1054/ijom.2003.0503
Khovidhunkit SP, Buajeeb W, Sanguansin S, et al Detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in Thai patients. Asian Pac J Cancer Prev 9:771–5
Krishna A, Singh R, Singh S et al (2014) Demographic risk factors, affected anatomical sites and clinicopathological profile for oral squamous cell carcinoma in a north Indian population. Asian Pac J Cancer Prev 15:6755–6760. https://doi.org/10.7314/APJCP.2014.15.16.6755
Manuel S, Raghavan SK, Pandey M, Sebastian P (2003) Survival in patients under 45 years with squamous cell carcinoma of the oral tongue. Int J Oral Maxillofac Surg 32:167–173. https://doi.org/10.1054/ijom.2002.0271
Sherin N, Simi T, Shameena P, Sudha S (2008) Changing trends in oral cancer. Indian J Cancer 45:93. https://doi.org/10.4103/0019-509X.44063
Patel SC, Carpenter WR, Tyree S, Couch ME, Weissler M, Hackman T, Hayes DN, Shores C, Chera BS (2011) Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years. J Clin Oncol 29:1488–1494. https://doi.org/10.1200/JCO.2010.31.7883
Durr ML, van Zante A, Li D, Kezirian EJ, Wang SJ (2013) Oral tongue squamous cell carcinoma in never-smokers. Otolaryngol Neck Surg 149:89–96. https://doi.org/10.1177/0194599813482876
Llewellyn CD, Johnson NW, Warnakulasuriya KA (2001) Risk factors for squamous cell carcinoma of the oral cavity in young people--a comprehensive literature review. Oral Oncol 37:401–418
Li R, Koch WM, Fakhry C, Gourin CG (2013) Distinct epidemiologic characteristics of oral tongue cancer patients. Otolaryngol Neck Surg 148:792–796. https://doi.org/10.1177/0194599813477992
GATS-2 Global Adult Tobacco Survey FACT SHEET INDIA 2016–17
Fan Y, Zheng L, Mao M-H, Huang MW, Liu SM, Zhang J, Li SL, Zheng L, Zhang JG (2014) Survival analysis of oral squamous cell carcinoma in a subgroup of young patients. Asian Pac J Cancer Prev 15:8887–8891. https://doi.org/10.7314/APJCP.2014.15.20.8887
Ganpathi Iyer S, Pradhan SA, Pai PS, Patil S (2004) Surgical treatment outcomes of localized squamous carcinoma of buccal mucosa. Head Neck 26:897–902. https://doi.org/10.1002/hed.20096
Feller L, Lemmer J (2012) Oral squamous cell carcinoma: epidemiology, clinical presentation and treatment. J Cancer Ther 3:263–268. https://doi.org/10.4236/jct.2012.34037
Iype EM, Pandey M, Mathew A, et al Oral cancer among patients under the age of 35 years. J Postgrad Med 47:171–6
Andreadis C, Vahtsevanos K, Sidiras T, Thomaidis I, Antoniadis K, Mouratidou D (2003) 5-Fluorouracil and cisplatin in the treatment of advanced oral cancer. Oral Oncol 39:380–385
Padma R, Thilagavathi R, Sundaresan S (2016) Survival outcomes of buccal mucosa carcinoma patients with multimodal therapy: an institutional study. Int J Nutr Pharmacol Neurol Dis 6:76. https://doi.org/10.4103/2231-0738.179967
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Bakshi, J., Kaur, N., Tiwana, H. et al. Survival Analysis of Oral Squamous Cell Carcinoma Patients Attending Tertiary Care Centre of North India. Indian J Surg Oncol 14, 234–242 (2023). https://doi.org/10.1007/s13193-020-01187-3
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DOI: https://doi.org/10.1007/s13193-020-01187-3