Indian Journal of Surgical Oncology

, Volume 9, Issue 2, pp 175–180 | Cite as

The Results of the Combine Treatment of Patients with Liver Bilobar Metastases from Colorectal Cancer Using Radiofrequency Ablation

  • Oleg Igorevich Kaganov
  • Sergei Vasilevich Kozlov
  • Andrei Evgenyevich Orlov
  • Nikita Vyacheslavovich Blinov
Original Article


Colorectal cancer (CRC) is the third most common cancer worldwide. The mortality from CRC remains very high. The main cause of such a high mortality is a disseminate process with the appearance of distant metastases. In this regard, the treatment of metastatic lesions is recognized as an important trend in modern oncology. The program of study included 176 patients with colorectal cancer after primary tumor removal with the malignant progression—multiple (more than 4) bilobar liver metastases. The research was organized in Samara Regional Oncology Centre from 2001 to 2014. By the treatment method, patients were divided into two groups. Main group got the combined (chemotherapy + radiofrequency ablation (RFA)) treatment (n = 98). In control group, only chemotherapy was applied (n = 78). One-, two-, and three-year OS were 73.5, 25.1, and 7.2% in the main group and 39.6, 6.3, and 2.1% in the control group. The RFA application allowed us to reach the index of 4-year survival 1.8% in the main group, while we received only 2.1 of 3-year survival in the control group. The OS median reached 18 months in the main group and 11 months in the control group. So, the OS curves in two comparing groups were significantly different according to statistics (log-rank test 3.77, р = 0.000). The application of RFA in combination with chemotherapy in the treatment of bilobar metastasis colorectal cancer allows to improve the performance of disease-free survival and overall survival significantly, compared with the group of patients who received only chemotherapy.


Colorectal cancer Liver bilobar metastases Radiofrequency ablation 


  1. 1.
    Vashakmadze LA, Trachtenberg AK, Chomyakov VM (2007) Cytoreductive surgery for metastatic colorectal cancer (review). Palliat Med Rehabil 1:40–50Google Scholar
  2. 2.
    Davydov MI, Axel EM (2011) Statistics malignancy in Russia and the CIS countries in 2009. Bulletin GU RCRC. Blokhin RAMN T.22.- №3(85) (ap.1):172Google Scholar
  3. 3.
    Chissov VI, Butenko AV, Vashakmadze LA et al (2010) Surgical treatment of primary and metastatic liver cancer. J Russian Cancer 5:8–12Google Scholar
  4. 4.
    Dolgushin BI, Patyutko YI, Sholokhov VN, Kosirev VY (2007) Radiofrequency thermoablation of liver tumors. Edited by MI Davydov. M.: Practical Medicine, pp 192Google Scholar
  5. 5.
    Gantsev Sh.Kh., Ishmuratova R.Sh., Rakhmatullina IR et al (2010) Short-term results of treatment of patients with liver metastases by radiofrequency thermoablation. Proceedings of the XVII International Congress of surgeons-hepatologists of CIS countries “Actual problems of surgical hepatology”. C 262–263Google Scholar
  6. 6.
    Gleisner AL, Choti MA, Assumpcao L et al (2008) Colorectal liver metastases: recurrence and survival following hepatic resection, radiofrequency ablation, and combined resection-radiofrequency ablation. Arch Surg 143(12):1204–1212CrossRefPubMedGoogle Scholar
  7. 7.
    The diagnosis and treatment of cancer. Clinical protocols. Edited by V.I. Chissov M .: FGBU “MNIOI them. P.A.Herzen” 2013. -599sGoogle Scholar
  8. 8.
    Kosirev VY, Dolgushin BI (2011) Features radiofrequency thermoablation of malignant liver tumors. Review of the literature. Med Imaging 3:24–37Google Scholar
  9. 9.
    Patyutko YI (2005) Surgical treatment of malignant liver tumors. M.: Pract Med 312Google Scholar
  10. 10.
    Adam R, Wicherts DA, de Haas RJ et al (2008) Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: myth or reality? J Clin Oncol 26:1635–1641CrossRefPubMedGoogle Scholar
  11. 11.
    Wisniewski VA, Fedorov AV, Ionkin DA et al (2010) Complications of radiofrequency thermoablation of liver malignancies. Surgery 2:18–29Google Scholar
  12. 12.
    Tyulyandin SA, Nosov DA, Perevodchikova NI (2009) The minimum clinical recommendations of the European Society for Medical Oncology (ESMO). editor Russian translation, Publishing Group RCRC. NN Blokhin RAMN.-M., pp 288Google Scholar
  13. 13.
    Siperstein AE, Berber E, Ballem N, Parikh RT (2007) Survival after radiofrequency ablation of colorectal liver metastases: 10 year experience. Ann Surg 246:559–565CrossRefPubMedGoogle Scholar
  14. 14.
    Tanaka K, Da Shima H, Ueda M et al (2008) Role of hepatectomy in treating multiple bilobar colorectal cancer metastases. Surgery 143:259–270CrossRefPubMedGoogle Scholar
  15. 15.
    Perevodchikova NI, Steninova MB (2014) Guidelines for chemotherapy of neoplastic diseases. Moscow: Practice.Google Scholar
  16. 16.
    Sidorov DV, Lozhkin MV, Grishin NA, Petrov LO et al. 2013 Results anatomical resection of liver metastases of colorectal cancer using the technique of water-jet dissection of the parenchyma. Oncology XXI century - from research into clinical practice, Materials of VIII Congress of Oncologists Russia 11–13 September 2013, SPb.: T.III. pp 998–999Google Scholar
  17. 17.
    Gillams AR, Lees WR (2009) Five year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation. Eur Radiol 19:1206–1213CrossRefPubMedGoogle Scholar
  18. 18.
    Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228–247CrossRefPubMedGoogle Scholar
  19. 19.
    Pozzo C, Barone C (2008) Advances in neoadjuvant therapy for colorectal cancer liver metastases. Cancer Treat Rev 34:293–301CrossRefPubMedGoogle Scholar

Copyright information

© Indian Association of Surgical Oncology 2018

Authors and Affiliations

  1. 1.Oncology DepartmentSamara State Medical UniversitySamaraRussian Federation
  2. 2.Samara Regional Oncology CentreSamaraRussian Federation

Personalised recommendations