Rare Case Report of Neuroendocrine Tumor in Axilla-Metastasis from Unknown Primary or De Novo?

  • Shreyas G Dholaria
  • Kamal Kishor Lakhera
  • Sanjeev Patni
Case report


Neuroendocrine tumors (NET) are the neoplasm arising from neuroendocrine cells which are present throughout the body. It can be benign, being more common or malignant. Gut is the most common site, but they can be seen in any part of the body. We had a case of grade III NET in axilla presented with a fungating lesion with unknown primary. Clinical behavior of such tumor is predicted by tumor grade or differentiation. We treated this patient by surgery and adjuvant chemotherapy.


Neuroendocrine tumour Neuroendocrine carcinoma NEC of axilla 


  1. 1.
    Koo HS, Sohn Y-M, Park Y-K (2014) Sonographic appearance of a neuroendocrine tumor arising in the axilla: case report and literature review. J Clin Ultrasound 42(1):30–32CrossRefPubMedGoogle Scholar
  2. 2.
    Spigel DR, Hainsworth JD, Greco FA (2009) Neuroendocrine carcinoma of unknown primary site. Semin Oncol 36(1):52–59CrossRefPubMedGoogle Scholar
  3. 3.
    Karthik KS, Kini H, Kini AU, Santosh P (2015) An unusual case of disseminated neuroendocrine tumor presenting with generalized lymphadenopathy. J Cancer Res Ther 11(3):669CrossRefPubMedGoogle Scholar
  4. 4.
    Eusebi V, Capella C, Cossu A, Rosai J (1992) Neuroendocrine carcinoma within lymph nodes in the absence of a primary tumor, with special reference to Merkel cell carcinoma. Am J Surg Pathol 16(7):658–666CrossRefPubMedGoogle Scholar
  5. 5.
    Öberg K, Castellano D (2011) Current knowledge on diagnosis and staging of neuroendocrine tumors. Cancer Metastasis Rev 30(S1):3–7CrossRefPubMedGoogle Scholar
  6. 6.
    Jernman J, Välimäki MJ, Louhimo J, Haglund C, Arola J (2012) The novel WHO 2010 classification for gastrointestinal neuroendocrine tumours correlates well with the metastatic potential of rectal neuroendocrine tumours. Neuroendocrinology 95(4):317–324CrossRefPubMedGoogle Scholar
  7. 7.
    Mitry E, Baudin E, Ducreux M, Sabourin J-C, Rufié P, Aparicio T et al (1999) Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin. Br J Cancer 81(8):1351–1355CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Stoyianni A, Pentheroudakis G, Pavlidis N (2011) Neuroendocrine carcinoma of unknown primary: a systematic review of the literature and a comparative study with other neuroendocrine tumors. Cancer Treat Rev 37(5):358–365CrossRefPubMedGoogle Scholar

Copyright information

© Indian Association of Surgical Oncology 2017

Authors and Affiliations

  • Shreyas G Dholaria
    • 1
  • Kamal Kishor Lakhera
    • 2
  • Sanjeev Patni
    • 3
  1. 1.Department Surgical oncologyBhagwan Mahaveer Cancer Hospital and Research CentreJaipurIndia
  2. 2.MCh Surgical OncologyBhagwan Mahaveer Cancer Hospital & Research CentreJaipurIndia
  3. 3.HOD Surgical Oncology DepartmentBhagwan Mahaveer Cancer Hospital & Research CentreJaipurIndia

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