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Identification and Quantification of Drug-Resistant Cells in Colorectal Tumor and Distal Margin

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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

Cancer stem cells are cellular subpopulations in tumor, which are highly tumorigenic and drug resistant due to their adaptive molecular mechanism. In the recent years, these cells have attracted researchers’ focus because of their unique properties which makes them biologically well evolved than other proliferating tumor cells. We have studied the presence of cancer stem cells in colorectal cancer (CRC) and its surgical margins. We report for the first time the presence of drug-resistant cells in distal resection margins in CRC and showed that a closer distal margin of less than 2 cm could have higher possibility of drug-resistant cells to spread.

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Acknowledgements

This project was supported by research fellowship from Department of Biotechnology (DBT), Government of India. The authors thank Indu Ramachandran for assistance in flow cytometry, RGCB, Trivandrum, India.

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Authors and Affiliations

  1. Regional Cancer Center, Trivandrum, Kerala, India

    K. Chandramohan

  2. Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India

    Tapas Pradhan & S. Asha Nair

Authors
  1. K. Chandramohan
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  2. Tapas Pradhan
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  3. S. Asha Nair
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Corresponding author

Correspondence to K. Chandramohan.

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The study protocol conformed to the guidelines of the ethics committee of each institution and was approved by each institution’s review board; all patients provided written informed consent.

Conflict of Interest

The authors declare that they have no conflict of interest.

Funding

This work was supported by extra mural fund from Department of Biotechnology (DBT), Government of India. (BT/PR3223/BRB/10/964/2011).

Additional information

K. Chandramohan and Tapas Pradhan are joined first authors

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Chandramohan, K., Pradhan, T. & Asha Nair, S. Identification and Quantification of Drug-Resistant Cells in Colorectal Tumor and Distal Margin. Indian J Surg Oncol 9, 141–145 (2018). https://doi.org/10.1007/s13193-017-0623-8

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  • DOI: https://doi.org/10.1007/s13193-017-0623-8

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