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Retroperitoneal Sarcoma. Outcome Analysis in a Teaching Hospital in Eastern India- a Perspective

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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

Primary Retroperitoneal Sarcomas are relatively uncommon tumors with varied manifestations, ill-defined prognostic factors and uncertain management modalities. We undertook this study to review patients who presented with primary or recurrent RPS at our institute during the study period. Between 2008 and 2010, 23 patients were evaluated. Statistical analysis was done using the chi square test or Fisher’s exact test. Recurrence was calculated using Kaplan Meier curves. The log-rank test was used to compare differences in survival or relapse. Among the 23 patients, 13 were males. Majority (52.2 %) presented with abdominal lump located in umbilical and right hypochondrial region. Surgery was done in 20 (87 %) patients for primary RPS and three (13 %) for recurrent RPS at initial presentation. 14 (61 %) received complete tumor resection, six (27 %) incomplete microscopic resection, and three (13 %) incomplete macroscopic resection. In univariate Cox’s proportional hazard model on time (‘timer’) to event (‘relapse’) analysis, all the variables like older age (p = 0.027), male sex (p = 0.012), incomplete resection (p = 0.008), large size (0.047) and high grade (p = 0.047) became significant predictor of early recurrence. However, multivariate analysis showed that only extent of resection, grade and sex were statistically significant predictors. Complete tumor resection of retroperitoneal sarcoma (n = 14) was associated with a significantly lesser recurrence compared with unclear resection (n = 9, p = 0.002). The median time between surgery and first recurrence was 15 months. High-grade sarcomas had a significantly higher recurrence (n = 10; median: 24, 95 % CI) than low-grade sarcomas (n = 13, median: 15; 95 %CI P < 0.01). Furthermore, the survival of male patients were worse than that of females (p = 0.036). Completeness of resection, tumor grade and sex are prognostic factors of retroperitoneal soft tissue sarcomas.

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Acknowledgments

This study has been approved by the appropriate ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study has omitted.

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  1. Nilanjan Panda

    Present address: , P 318 B, CIT Road, Scheme 6 M, Kankurgachi, Kolkata, 700054, India

Authors and Affiliations

  1. R.G Kar Medical College, Kolkata, India

    Nilanjan Panda & Samik Kumar Bandyopadhyay

  2. B.S Medical College, Gobindonagar, Bankura, West Bengal, India

    Ruchira Das

  3. Indian Institute of Public Health, Hyderabad, India

    Souvik Banerjee

  4. N.R.S Medical College, Kolkata, India

    Sajib Chatterjee & Manas Gumta

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  1. Nilanjan Panda
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Correspondence to Nilanjan Panda.

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Panda, N., Das, R., Banerjee, S. et al. Retroperitoneal Sarcoma. Outcome Analysis in a Teaching Hospital in Eastern India- a Perspective. Indian J Surg Oncol 6, 99–105 (2015). https://doi.org/10.1007/s13193-015-0404-1

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  • DOI: https://doi.org/10.1007/s13193-015-0404-1

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