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Role of NF-κB as a Prognostic Marker in Breast Cancer : A Pilot Study in Indian Patients

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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

The nuclear factor κB (NF-κB) is a superfamily of transcription factors. It plays an important role in development & progression of cancer. This study was conducted in a tertiary care centre to investigate the significance of NF-κB as a prognostic marker in breast cancer and study its relation with established prognostic markers such as tumor grade, lymph node status, hormone receptor & HER-2/neu expression. We measured NF-κB expression of breast cancer tissue as a test sample & from fibroadenoma as a control. Measurement was done by Western Blot Technique using p65 protein of NF-κB super family of transcription factors. ER,PR and HER-2/neu were measured by immunohistochemistry methods. NF-κB/p65 is significantly associated with large tumor size (≥5 cm), high grade tumors, negative ER, negative PR, positive HER-2/neu and high NPI (≥5.4) scores. NF-κB/p65 expression implies aggressive biological behaviour of breast cancer & this study validates significant association of NF-κB /p65 overexpression with large tumor size, negative estrogen & progesterone receptor status and overexpression of c-erbB2 oncoprotein.

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Authors and Affiliations

  1. Comprehensive Breast Clinic Service & Breast Cancer Research Unit, IPGME&R & SSKM Hospital, Kolkata, West Bengal, India

    D. K. Sarkar, Debarshi Jana, P. S. Patil, K. S. Chaudhari, B. K. Chattopadhyay, B. R. Chikkala & P. Chowdhary

  2. Department of Epidemiology and Biostatistics, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India

    S. Mandal

  3. Type 5, Bldg. No. 5, Flat No. 20, R.C.F. Colony, Officers’ Qtrs., Chembur, Mumbai, 400074, Maharashtra, India

    K. S. Chaudhari

  4. 396/3,N.S.C.Bose Road, Kolkata, 700047, West Bengal, India

    D. K. Sarkar

  5. 1, Thakurbari Road, P.O.Kalighat, Kolkata, 700026, West Bengal, India

    Debarshi Jana

  6. Junior Doctors’ Hostel, Room No. 335, 242,A.J.C.Bose Road, Kolkata, 700020, West Bengal, India

    P. S. Patil

  7. Department of General Surgery, IPGME&R and SSKM Hospital, 244, A.J.C.Bose Road, Kolkata, West Bengal, India

    B. K. Chattopadhyay & P. Chowdhary

  8. Junior Doctors’ Hostel, Room No. 208, 242, A.J.C.Bose Road, Kolkata, 700020, West Bengal, India

    B. R. Chikkala

Authors
  1. D. K. Sarkar
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  2. Debarshi Jana
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  3. P. S. Patil
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  4. K. S. Chaudhari
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  5. B. K. Chattopadhyay
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  6. B. R. Chikkala
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  7. S. Mandal
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  8. P. Chowdhary
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Corresponding author

Correspondence to K. S. Chaudhari.

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Sarkar, D.K., Jana, D., Patil, P.S. et al. Role of NF-κB as a Prognostic Marker in Breast Cancer : A Pilot Study in Indian Patients. Indian J Surg Oncol 4, 242–247 (2013). https://doi.org/10.1007/s13193-013-0234-y

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  • DOI: https://doi.org/10.1007/s13193-013-0234-y

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