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Prognostic Value of Patient Knowledge of Cancer on Quality of Life in Advanced Lung Cancer During Chemotherapy

Abstract

The purpose of the study was to assess the impact of cancer knowledge and patient’s lifestyle on QOL and the relationship between QOL and various environmental factors in patients with non-small-cell lung cancer treated with chemotherapy. The study group consisted of 129 patients with metastatic lung cancer patients treated between May 2010 and December 2015 in two centres. The knowledge of cancer and their lifestyle was rated by method of diagnostic survey, using the Behavioral Health Inventory IZZ by Prof. Juczyński. We sought factors affecting to response to treatment, overall survival and quality of life. The general level of knowledge of cancer and the level of health behaviours was low. Ninety percent of lung cancer patients were smokers. The average age of the study group was 64 years. Eighty-nine patients received chemotherapy with cisplatin, 28 schemes containing carboplatin, 6 inhibitors of EGFR tyrosine kinase, and 6 vinorelbine or gemcitabine monotherapy. Complete regression was observed in 2 patients, partial response in 33 patients (26%), stable disease in 51 (40%) and 54 (42%) patients had progression. In multivariate analysis, significant effects on survival were performance status, schemes of treatment and response to treatment. Quality of life before and after treatment did not differ from each other. We found impact on quality of life: performance status, response to treatment and knowledge of cancer and lifestyle. The level of knowledge of oncological patients and their lifestyle observed in clinical practice are associated with QOL.

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Abbreviations

NSCLC:

Non-small-cell lung carcinoma

EGFR:

Epidermal growth factor receptor

ALK:

Anaplastic lymphoma kinase

QOL:

Quality of life

HBI:

Questionnaire Health Behaviour Inventory by Prof. Z. Juczyński

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Funding

Dr. Adamowicz is not currently in receipt of any research funding.

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Contributions

Krzysztof Adamowicz—contributed for the idea, data collection, data analysis and revision of the final text.

Justyna Janiszewska—interviewer, psychologist and interpretation of data.

Monika Lichodziejewska-Niemierko—content supervisor.

Corresponding author

Correspondence to Krzysztof Adamowicz.

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Bioethical Commission at the District Chamber of Physicians in Gdansk.

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The author declares no conflict of interest.

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Adamowicz, K., Janiszewska, J. & Lichodziejewska-Niemierko, M. Prognostic Value of Patient Knowledge of Cancer on Quality of Life in Advanced Lung Cancer During Chemotherapy. J Canc Educ 35, 93–99 (2020). https://doi.org/10.1007/s13187-018-1444-3

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Keywords

  • Lung cancer
  • Chemotherapy
  • Treatment outcomes
  • Quality of life
  • Knowledge of cancer