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Kratom Adulterated with Phenylethylamine and Associated Intracerebral Hemorrhage: Linking Toxicologists and Public Health Officials to Identify Dangerous Adulterants

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Abstract

Introduction

Kratom is derived from the plant Mitragyna speciosa which is indigenous to Southeast Asia. Active compounds, mitragynine and 7-hydroxymitragynine, cause mild stimulant and opioid agonist effects. Although reported to have potential benefits in the treatment of opioid use disorder, efficacy remains uncertain while adverse health effects have been reported. A compounding concern is the presence of adulterants given that this is an unregulated product.

Case Details

A 54-year-old fitness instructor who used an online purchased kratom product regularly for one year developed stimulatory effects and suffered a large hemorrhagic stroke with a close temporal relationship to ingestion of a different kratom product from the one he regularly used. A collaborative investigation by medical toxicologists, a regional poison center, the state public health laboratory, and public health officials determined that his new kratom product was adulterated with phenylethylamine (PEA).

Discussion

We report a case of PEA adulterated kratom purchased and used with resultant adverse effects. PEA is structurally similar to amphetamine and is known to produce sympathomimetic effects. It is possible the stimulatory effect of PEA resulted in a marked and transient increase in blood pressure resulting in hemorrhagic stroke.

Conclusion

Medical toxicologists should form working relationships with laboratories and public health officials to aid in early identification of adulterated products that carry risk to the general population.

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Abbreviations

US:

United States

ICU:

Intensive care unit

OUD:

Opioid use disorder

PEA:

Phenylethylamine

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Correspondence to Nicholas Nacca.

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Consent for publication of this case was obtained from the patient and family and provided to the journal in accordance with JMT policy.

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Supervising Editor: Andis Graudins, MB BS, PhD

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Nacca, N., Schult, R.F., Li, L. et al. Kratom Adulterated with Phenylethylamine and Associated Intracerebral Hemorrhage: Linking Toxicologists and Public Health Officials to Identify Dangerous Adulterants. J. Med. Toxicol. 16, 71–74 (2020). https://doi.org/10.1007/s13181-019-00741-y

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  • DOI: https://doi.org/10.1007/s13181-019-00741-y

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