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The Importance of Recognizing Cannabinoid Hyperemesis Syndrome from Synthetic Marijuana Use

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  1. 1.

    Sorensen CJ, DeSanto K, Borgelt L, Phillips KT, Monte AA. Cannabinoid hyperemesis syndrome: diagnosis, pathophysiology, and treatment—a systematic review [published online Dec 20 2016]. J Med Toxicol. 2016; doi:10.1007/s13181-016-0595-z.

    PubMed  Google Scholar 

  2. 2.

    Guyatt GH, Oxman AD, Kunz R, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924–6.

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Odgen DW. Memorandum for selected United States attorneys on investigations and prosecutions in states authorizing the medical use of marijuana. Department of Justice. 2009. Accessed 03 March, 2017.

  4. 4.

    Fairman BJ. Trends in registered medical marijuana participation across 13 US states and District of Columbia. Drug Alcohol Depend. 2016;159:72–9.

    Article  PubMed  Google Scholar 

  5. 5.

    Healthcare cost and utilization project. National inpatient sample. Agency of Healthcare Research and Quality; Rockville. Accessed 03 March, 2017.

  6. 6.

    Hopkins CY, Gilchrist BL. A case of cannabinoid hyperemesis syndrome caused by synthetic cannabinoids. J Emerg Med. 2013;45(4):544–6.

    Article  PubMed  Google Scholar 

  7. 7.

    Ukaigwe A, Karmacharya P, Donato A. A gut gone to pot: a case of cannabinoid hyperemesis syndrome due to K2, a synthetic cannabinoid. Case Reports in Emergency Medicine. 2014; Article ID 167098 doi:10.1155/2014/167098.

    PubMed  PubMed Central  Google Scholar 

  8. 8.

    Bick BL, Szostek JH, Mangan TF. Synthetic cannabinoid leading to cannabinoid hyperemesis syndrome. Mayo Clin Proc. 2014;89(8):1168–9.

    Article  PubMed  Google Scholar 

  9. 9.

    Mills B, Yepes A, Nugent K. Synthetic cannabinoids. Am J Med Sci. 2015;350(1):59–62.

    Article  PubMed  Google Scholar 

  10. 10.

    Forrester MB, Kleinschmidt K, Schwarz E, et al. Synthetic cannabinoid and marijuana exposures reported to poison centers. Hum Exp Toxicol. 2012;31:1006–11.

    CAS  Article  PubMed  Google Scholar 

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Correspondence to Ji Yoo.

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Liu, X., Villamagna, A. & Yoo, J. The Importance of Recognizing Cannabinoid Hyperemesis Syndrome from Synthetic Marijuana Use. J. Med. Toxicol. 13, 199–200 (2017).

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  • Urine Drug Screen
  • Marijuana User
  • Persistent Vomiting
  • Medical Marijuana
  • National Inpatient Sample