Abstract
Evidence suggests that in-utero exposure to environmental chemicals, such as persistent organic pollutants (POPs), heavy metals, and radionuclides, that might bioaccumulate in the mother may increase a newborn's risk of adverse developmental, neurological, and immunologic effects. Chemical contamination of bodies of water and strong ocean currents worldwide can drive these chemicals from lower latitudes to Arctic waters where they accumulate in common traditional subsistence foods. In response to concerns of the people from Alaska of the effects of bio-accumulated chemicals on their children, the Maternal Organics Monitoring Study(MOMS) was developed. The objective of the study was to assess the risks and benefits associated with the population's subsistence diet. Data analysis of biological samples at the CDC's NCEH laboratory and maternal questionnaires is ongoing. Results will be provided to Alaska Native communities to help support public health actions and inform future interventions and research.
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References
AMAP Assessment 2015: Human health in the Arctic. Arctic Monitoring and Assessment Programme (AMAP), Oslo, Norway. vii + 165 pp.
Heiman M, Wright BA. Contaminants in Alaska—is America’s Arctic at risk? Interagency Collaborative Paper. 2000. http://www.akaction.org/wp-content/uploads/2015/07/Contaminants_in_Alaska.pdf. Accessed 18 Apr 2016.
Nadal M, Marquès M, Mari M, Domingo JL. Climate change and environmental concentrations of POPs: a review. Environ Res. 2015 Nov;143(Pt A):177–185.
Johnson BL, Hicks HE, Jones DE, Cibulas W, Wargo A, DeRosa CT. Public health implications of persistent toxic substances in the Great Lakes and St. Lawrence basins. J Great Lakes Res. 1998;24(2):698–722.
Gerhard I, Daniel V, Link S, Monga B, Runnebaum B. Chlorinated hydrocarbons in women with repeated miscarriages. Environ Health Perspect. 1998;106(10):675–81.
Rogan WJ, Gladen BC. Study of human lactation for effects of environmental contaminants: the North Carolina Breast Milk and Formula Project and some other ideas. Environ Health Perspect. 1985;60:215–21.
Rogan WJ, Gladen BC, McKinney JD, Carreras N, Hardy P, Thullen J, Tingelstad J, Tully M. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr. 1986;109(2):335–41.
Fein GG, Jacobson JL, Jacobson SW, Schwartz PM, Dowler JK. Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestation age. J Pediatr. 1984;105(2):315–20.
Jacobson SW, Fein GG, Jacobson JL, Schwartz PM, Dowler JK. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985;56(4):853–60.
Jacobson JL, Jacobson SW, Humphrey HEB. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive-functioning in young children. J Pediatr. 1990;116(1):38–45.
Jacobson JL, Jacobson SW, Humphrey HEB. Effects of exposure to PCBs and related compounds on growth and activity in children. Neurotoxicol Teratol. 1990;12(4):319–26.
Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996;335(11):783–9.
Smith BJ. PCB levels in human fluids: Sheboygan case study. Technical report WIS-SG-83-240. Madison: University of Wisconsin Sea Grant Institute; 1984.
Dewailly E, Nantel AJ, Weber JP, Meyer F. High levels of PCBs in breast milk of Inuit women from Arctic Quebec. Bull Environ Contam Toxicol. 1989;43(5):641–6.
Agency for Toxic Substances and Disease Registry. Toxicological profile for lead. Atlanta: US Department of Health and Human Services, Public Health Service. 2007. http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf. Accessed 18 Apr 2016.
Kaufman AS. Do low levels of lead produce IQ loss in children? A careful examination of the literature. Arch Clin Neuropsychol. 2001;16(4):303–41.
Grandjean P, Weihe RF, White F, Debes S, Araki K, Yokoyama K, Murata N, Sørensen N, Dahl R, Jørgensen PJ. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997;19(6):417–28.
Strand P, Howard BJ, Aarkrog A, Balonov M, Tsaturov Y, Bewers JM, Salo A, Sickel M, Bergman R, Rissanen K. Radioactive contamination in the Arctic—sources, dose assessment and potential risks. J Environ Radioact. 2002;60(1–2):5–21.
Van Oostdam J, Gilman A, Dewailly E, Usher P, Wheatley B, Kuhnlein H, Neve S, Walker J, Tracy B, Feeley M, Jerome V, Kwavnick B. Human health implications of environmental contaminants in Arctic Canada: a review. Sci Total Environ 1999 Jun 1;230(1–3):1–82.
Tolstykh EI, Shagina NB, Degteva MO. Increase in accumulation of strontium-90 in the maternal skeleton during pregnancy and lactation: analysis of the Techa River data. Radiat Environ Biophys 2014 Aug;53(3):551–557.
Kossenko MM, Izhevsky PV, Degteva MO, Akleev AV, Vyushkova OV. Pregnancy outcome and early health status of children born to the Techa River population. Sci Total Environ 1994 Mar 1;142(1–2):91–100.
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Feature Editor: Joshua G. Schier, MD MPH
Contributors: Mehruba Anwar MD, Alison Ridpath MD MPH, James Berner MD
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Anwar, M., Ridpath, A., Berner, J. et al. Medical Toxicology and Public Health—Update on Research and Activities at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry. J. Med. Toxicol. 12, 315–317 (2016). https://doi.org/10.1007/s13181-016-0562-8
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DOI: https://doi.org/10.1007/s13181-016-0562-8