Abstract
Introduction
Over the last decade, there has been a reduction of organ donation from intracranial haemorrhage-, stroke- and blunt trauma-related deaths in the USA. There has been a corresponding increase in the use of drug-intoxicated patients as organ donors from 2.1 % in 2003 to 6.8 % in 2013.
Methods
Questionnaire survey of attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting breakout session on transplantation from deaths related to poisoning was performed. Participants were asked whether they would recommend the use of solid organs from cocaine- or carbon monoxide-related death before and after the breakout session.
Results
Forty-eight US participants (attending 23, fellow 15, resident 3 and other (including non-medical) 7) completed the survey, and 97.8 and 89.1 % of participants would consider cocaine- and carbon monoxide-related deaths for potential organ donation pre-breakout session, respectively; this increased to 100 % for both post-breakout sessions. There was variability in the consideration of different solid organs (the heart, lungs, liver, pancreas and kidneys)—76.2–95.2 and 76.2–85.7 % for individual solid organs for cocaine- and carbon monoxide-related deaths, respectively. For both scenarios, participants were least likely to consider potential heart donation (76.2 % of participants for both), which increased to 100 % following the breakout session.
Conclusions
Medical toxicologists have some reservation in recommending solid organs for transplantation from deaths from cocaine and carbon monoxide. Given the decrease in potential organ donors from typical methods of death, further work is needed to promote organ donation in deaths related to acute poisoning.
Similar content being viewed by others
References
US Department of Health and Human Sciences and Health Resources and Services Administration (2014) Organ Procurement and Transplantation Network. http://optn.transplant.hrsa.gov/. Accessed 6 June 2014
Hantson P, Mahieu P, Hassoun A, Otte JB (1995) Outcome following organ removal from poisoned donors in brain death status: a report of 12 cases and review of the literature. J Toxicol Clin Toxicol 33:709–712
Wood DM, Dargan PI, Jones AL (2003) Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units. Crit Care 7:147–154
Klimaszyk D, Łukasik-Głebocka M (2013) Acute poisonings and organ donation—case reports and literature review. Przegl Lek 70:674–678
López-Navidad A, Caballero F (2003) Extended criteria for organ acceptance. Strategies for achieving organ safety and for increasing organ pool. Clin Transplant 17:308–324
Luckraz H, Tsui SS, Parameshwar J, Wallwork J, Large SR (2001) Improved outcome with organs from carbon monoxide poisoned donors for intrathoracic transplantation. Ann Thorac Surg 72:709–713
Xu DS, Hartman D, Ludrosky K, Campbell J, Starling RC, Taylor DO, Smedira NG, Gonzalez-Stawinski GV (2010) Impact of donor high-risk social behaviors on recipient survival in cardiac transplantation. Transplantation 89:873–878
Brieke A, Krishnamani R, Rocha MJ, Li W, Patten RD, Konstam MA, Patel AR, Udelson JE, Denofrio D (2008) Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry. J Heart Lung Transplant 27:1350–1352
Lee TJ, Fox MP, Trivedi J, van Berkel V (2012) Donors with a history of cocaine use and lung transplant outcomes. J Heart Lung Transplant 31:1144–1146
Busche MN, Knobloch K, Herold C, Krämer R, Vogt PM, Rennekampff HO (2011) Solid organ procurement from donors with carbon monoxide poisoning and/or burn—a systematic review. Burns 37:814–822
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wood, D.M., Chan, W.L. & Dargan, P.I. Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting. J. Med. Toxicol. 10, 360–363 (2014). https://doi.org/10.1007/s13181-014-0413-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13181-014-0413-4