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Baking Soda Can Settle the Stomach but Upset the Heart: Case Files of the Medical Toxicology Fellowship at the University of California, San Francisco

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References

  1. 1.

    ARM & HAMMER® Baking soda package. http://www.armandhammer.com/solutions/solution-53/Antacid.aspx. Accessed 9 Oct 2012

  2. 2.

    Sodium bicarbonate tablet [Rugby Laboratories, Inc.] Drug fact sheet. http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=33107. Accessed 9 Oct 2012

  3. 3.

    Fitzgibbons LJ, Snoey ER (1999) Severe metabolic alkalosis due to baking soda ingestion: case reports of two patients with unsuspected antacid overdose. J Emerg Med 17(1):57–61

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Thomas SH, Stone CK (1994) Acute toxicity from baking soda ingestion. Am J Emerg Med 12(1):57–59

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Ajbani K, Chansky ME, Baumann BM (2011) Homespun remedy, homespun toxicity: baking soda ingestion for dyspepsia. J Emerg Med 40(4):e71–e74

    PubMed  Article  Google Scholar 

  6. 6.

    Booth BE, Gates J, Morris RC Jr (1984) Grocery store baking soda a source of sodium bicarbonate in the management of chronic metabolic acidosis. Clin Pediatr (Phila) 23(2):94–96

    Article  CAS  Google Scholar 

  7. 7.

    Razzavi B (2000) Letter to editor. Baking soda toxicity. Am J Med 108(9):756–757

    Article  Google Scholar 

  8. 8.

    Gonzalez J, Hogg RJ (1981) Metabolic alkalosis secondary to baking soda treatment of a diaper rash. Pediatrics 67(6):820–822

    PubMed  CAS  Google Scholar 

  9. 9.

    Abreo K, Adlakha A, Kilpatrick S, Flanagan R, Webb R, Shakamuri S (1993) The milk alkali syndrome. A reversible form of acute renal failure. Arch Intern Med 153(8):1005–1010

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Khanna A, Kurtzman NA (2006) Metabolic alkalosis. J Nephrol 19(Suppl 9):S86–S96

    PubMed  CAS  Google Scholar 

  11. 11.

    Gawarammana IB, Coburn J, Greene S, Dargan PI, Jones AL (2007) Severe hypokalaemic metabolic alkalosis following ingestion of Gaviscon®. Clin Toxicol (Phila) 45(2):176–178

    Article  CAS  Google Scholar 

  12. 12.

    Mennen M, Slovis CM (1988) Severe metabolic alkalosis in the emergency department. Ann Emerg Med 17(4):354–357

    PubMed  Article  CAS  Google Scholar 

  13. 13.

    Burnell JM, Scribner BH, Uyeno BT, Villamil MF (1956) The effect in humans of extracellular pH change on the relationship between serum potassium concentration and intracellular potassium. J Clin Invest 35(9):935–939

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Aronson PS, Giebisch G (2011) Effects of pH on potassium: new explanations for old observations. J Am Soc Nephrol 22(11):1981–1989

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Yi JH, Han SW, Song JS, Kim HJ (2012) Metabolic alkalosis from unsuspected ingestion: use of urine pH and anion gap. Am J Kidney Dis 59(4):577–581

    PubMed  Article  Google Scholar 

  16. 16.

    Palmer BF, Alpern RJ (1997) Metabolic alkalosis. J Am Soc Nephrol 8(9):1462–1469

    PubMed  CAS  Google Scholar 

  17. 17.

    Gennari FJ (2011) Pathophysiology of metabolic alkalosis: a new classification based on the centrality of stimulated collecting duct ion transport. Am J Kidney Dis 58(4):626–636

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Luke RG, Galla JH (2012) It is chloride depletion alkalosis, not contraction alkalosis. J Am Soc Nephrol 23(2):204–207

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Kaye M, Somerville PJ, Lowe G, Katis M, Schneider W (1997) Hypocalcemic tetany and metabolic alkalosis in a dialysis patient: an unusual event. Am J Kidney Dis 30(3):440–444

    PubMed  Article  CAS  Google Scholar 

  20. 20.

    Nicholas MH, Wason S, Gonzalez del Rey J, Benfield M (1995) Baking soda a potentially fatal home remedy. Pediatr Emerg Care 11(2):109–111

    Article  Google Scholar 

  21. 21.

    Puczynski MS, Cunningham DG, Mortimer JC (1983) Sodium intoxication caused by use of baking soda as a home remedy. Can Med Assoc J 128(7):821–822

    PubMed  CAS  Google Scholar 

  22. 22.

    Fuchs S, Listernick R (1978) Hypernatremia and metabolic alkalosis as a consequence of the therapeutic misuse of baking soda. Pediatr Emerg Care 3(4):242–243

    Article  Google Scholar 

  23. 23.

    Assadi F (2012) Hyponatremia: a problem-solving approach to clinical cases. J Nephrol 25(4):473–480

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Pappano D (2011) Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis. Pediatr Emerg Care 27(2):124

    PubMed  Article  Google Scholar 

  25. 25.

    Javoaheri S, Shore NS, Rose B, Kazemi H (1982) Compensatory hypoventilation in metabolic alkalosis. Chest 81(3):296–301

    Article  Google Scholar 

  26. 26.

    Perrone J, Hoffman RS (1996) Compensatory hypoventilation in severe metabolic alkalosis. Acad Emerg Med 3(10):981–982

    PubMed  Article  CAS  Google Scholar 

  27. 27.

    Khanna A, Kurtzman NA (2001) Metabolic alkalosis. Respir Care 46(4):354–365

    PubMed  CAS  Google Scholar 

  28. 28.

    Niewiński G, Korta T, Debowska M, Kosiński C, Kubik T, Romanik W, Kański A (2008) Cardiac arrest in chronic metabolic alkalosis due to sodium bicarbonate abuse. Anestezjol Intens Ter 40(3):173–177 (Article in Polish, Abstract in English)

    PubMed  Google Scholar 

  29. 29.

    Forslund T, Koistinen A, Anttinen J, Wagner B, Miettinen M (2008) Forty years abuse of baking soda, rhabdomyolysis, glomerulonephritis, hypertension leading to renal failure: a case report. Clin Med: Case Rep 1:83–87

    Google Scholar 

  30. 30.

    Johnson BE (1989) Resistant hypertension due to pica (baking soda). Lancet 1(8637):550–551

    PubMed  Article  CAS  Google Scholar 

  31. 31.

    Grotegut CA, Dandolu V, Katari S, Whiteman VE, Geifman-Holtzman O, Teitelman M (2006) Baking soda pica, a case of hypokalemic metabolic alkalosis and rhabdomyolysis in pregnancy. Obstet Gynecol 107(2pt2):484–486

    PubMed  Google Scholar 

  32. 32.

    Lazebnik N, Lellin A, Michowitz M (1986) Spontaneous rupture of the normal stomach after sodium bicarbonate ingestion. J Clin Gastroenterol 8(4):454–456

    PubMed  Article  CAS  Google Scholar 

  33. 33.

    Food and Drug Administration (1994) Antacid drug products for over-the-counter human use. Fed Regist 59(22)

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Correspondence to Kent R. Olson.

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Al-Abri, S.A., Olson, K.R. Baking Soda Can Settle the Stomach but Upset the Heart: Case Files of the Medical Toxicology Fellowship at the University of California, San Francisco. J. Med. Toxicol. 9, 255–258 (2013). https://doi.org/10.1007/s13181-013-0300-4

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Keywords

  • Baking soda
  • Metabolic alkalosis
  • Sodium bicarbonate
  • Hypochloremia