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Détection fortuite de cmy-2 et dha-1 chez des isolats d’Escherichia coli producteurs de BLSE au Sénégal

Fortuitous Detection of cmy-2 and dha-1 from ESBL-producing Escherichia coli in Senegal

  • Bactériologie / Bacteriology
  • Published:
Bulletin de la Société de pathologie exotique

Résumé

Les céphalosporinases, naturellement présentes chez certaines espèces d’entérobactéries, peuvent être mobilisées par les transposons, migrer sur les plasmides et diffuser au sein d’autres espèces comme Escherichia coli. L’objectif de cette étude était de caractériser les gènes responsables de la production de β-lactamases à spectre étendu (BLSE) chez des isolats d’E. coli d’origine urinaire, isolés dans deux hôpitaux du Sénégal. Ainsi, une découverte fortuite de céphalosporinases plasmidiques chez deux isolats a été notée. L’un des isolats produisait la dha-1 associée à la BLSE CTX-M-14, et l’autre produisait la cmy-2, la BLSE CTX-M-15, une pénicillinase de type tem-1 et une oxacillinase de type oxa-1. Ces résultats confirment la circulation de bactéries multirésistantes productrices de céphalosporinases plasmidiques au Sénégal. Cependant, une étude plus élargie doit être menée pour mieux connaître la prévalence et la nature des gènes impliqués.

Abstract

Cephalosporinases, which are naturally present in some enterobacterial species, can be mobilized by transposons, migrate to plasmids, and spread into other species such as Escherichia coli. The aim of this study was to characterize genes responsible for the production of extended-spectrum β-lactamases (ESBL) in E. coli isolates from urinary origin isolated in two hospitals in Senegal. Thus, a fortuitous discovery of plasmidic cephalosporinase in two isolates was noted. One of the isolates produced dha-1 associated with ESBL CTX-M-14, the other produced cmy-2, ESBL CTXM-15, tem-1 penicillinase, and oxa-1. This confirms the circulation of multidrug-resistant bacteria producing plasmidic cephalosporinase in Senegal. However, a large study is needed to better understand the prevalence and the nature of the genes involved.

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Authors and Affiliations

  1. UFR sciences de la santé, université Gaston-Berger, BP 234, Saint Louis, Sénégal

    S. Lo

  2. CNR de la résistance des entérobactéries, 63003, Clermont-Ferrand, France

    F. Robin, R. Beyrouthy & R. Bonnet

  3. Faculté de médecine, de pharmacie et d’odontologie, UCAD, Dakar, Sénégal

    A. Ba-Diallo, M.L. Dia, A. Gaye-Diallo & A.I. Sow

  4. Laboratoire de biologie, centre hospitalier régional de Saint-Louis, Saint-Louis, Sénégal

    O.F. Diallo

Authors
  1. S. Lo
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  2. F. Robin
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  3. A. Ba-Diallo
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  4. O.F. Diallo
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  5. M.L. Dia
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  6. R. Beyrouthy
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  7. A. Gaye-Diallo
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  8. A.I. Sow
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  9. R. Bonnet
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Correspondence to S. Lo.

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Lo, S., Robin, F., Ba-Diallo, A. et al. Détection fortuite de cmy-2 et dha-1 chez des isolats d’Escherichia coli producteurs de BLSE au Sénégal. Bull. Soc. Pathol. Exot. 110, 221–223 (2017). https://doi.org/10.1007/s13149-017-0573-y

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  • DOI: https://doi.org/10.1007/s13149-017-0573-y

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